Overcoming immunological barriers in regenerative medicine Journal Article

   


Authors: Zakrzewski, J. L.; van den Brink, M. R. M.; Hubbell, J. A.
Article Title: Overcoming immunological barriers in regenerative medicine
Abstract: Regenerative therapies that use allogeneic cells are likely to encounter immunological barriers similar to those that occur with transplantation of solid organs and allogeneic hematopoietic stem cells (HSCs). Decades of experience in clinical transplantation hold valuable lessons for regenerative medicine, offering approaches for developing tolerance-induction treatments relevant to cell therapies. Outside the field of solid-organ and allogeneic HSC transplantation, new strategies are emerging for controlling the immune response, such as methods based on biomaterials or mimicry of antigen-specific peripheral tolerance. Novel biomaterials can alter the behavior of cells in tissue-engineered constructs and can blunt host immune responses to cells and biomaterial scaffolds. Approaches to suppress autoreactive immune cells may also be useful in regenerative medicine. The most innovative solutions will be developed through closer collaboration among stem cell biologists, transplantation immunologists and materials scientists. © 2014 Nature America, Inc.
Keywords: cytology; immune system; hematopoietic stem cells; stem cells; regenerative medicine; biomaterials; biological materials; host immune response; biomaterial scaffolds; innovative solutions; materials scientist; stem cell biologists; tissue-engineered constructs; scaffolds (biology)
Journal Title: Nature Biotechnology
Volume: 32
Issue: 8
ISSN: 1087-0156
Publisher: Nature Publishing Group  
Date Published: 2014-08-05
Start Page: 786
End Page: 794
Language: English
DOI: 10.1038/nbt.2960
PROVIDER: scopus
PUBMED: 25093888
PMCID: PMC4409427
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84905733690&partnerID=40&md5=497176fc506b8a77d38a2ce2529c1575
Notes: Export Date: 2 September 2014 -- CODEN: NABIF -- Source: Scopus
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MSK Authors
  1. Marcel R M Van Den Brink
    616 Van Den Brink
  2. Johannes Lothar Zakrzewski
    57 Zakrzewski
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