Dawn of advanced molecular medicine: Nanotechnological advancements in cancer imaging and therapy Journal Article


Authors: Kaittanis, C.; Shaffer, T. M.; Thorek, D. L. J.; Grimm, J.
Article Title: Dawn of advanced molecular medicine: Nanotechnological advancements in cancer imaging and therapy
Abstract: Nanotechnology plays an increasingly important role not only in our everyday life (with all its benefits and dangers) but also in medicine. Nanoparticles are to date the most intriguing option to deliver high concentrations of agents specifically and directly to cancer cells; therefore, a wide variety of these nanomaterials has been developed and explored. These span the range from simple nanoagents to sophisticated smart devices for drug delivery or imaging. Nanomaterials usually provide a large surface area, allowing for decoration with a large amount of moieties on the surface for either additional functionalities or targeting. Besides using particles solely for imaging purposes, they can also carry as a payload a therapeutic agent. If both are combined within the same particle, a theranostic agent is created. The sophistication of highly developed nanotechnology targeting approaches provides a promising means for many clinical implementations and can provide improved applications for otherwise suboptimal formulations. In this review we will explore nanotechnology both for imaging and therapy to provide a general overview of the field and its impact on cancer imaging and therapy. © 2014 by Begell House, Inc.
Keywords: chemotherapy; oncology; nanoparticles; drug delivery; targeted therapeutics
Journal Title: Critical Reviews in Oncogenesis
Volume: 19
Issue: 3-4
ISSN: 0893-9675
Publisher: Begell House, Inc  
Date Published: 2014-01-01
Start Page: 143
End Page: 176
Language: English
DOI: 10.1615/CritRevOncog.2014011601
PROVIDER: scopus
PMCID: PMC4183929
PUBMED: 25271430
DOI/URL:
Notes: Export Date: 2 September 2014 -- CODEN: CRONE -- Source: Scopus
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MSK Authors
  1. Daniel Thorek
    20 Thorek
  2. Jan Grimm
    55 Grimm
  3. Travis Michael Shaffer
    14 Shaffer