Abstract: |
Nanomaterials have garnered increasing interest recently as potential therapeutic drug-delivery vehicles. Among the existing nanomaterials are the pure carbon-based particles, such as fullerenes and nanotubes, various organic dendrimers, liposomes and other polymeric compounds. These vehicles have been decorated with a wide-spectrum of target-reactive ligands, such as antibodies and peptides, which interact with cell-surface tumor antigens or vascular epitopes. Once targeted, these new nanomaterials can then deliver radioisotopes or isotope generators to the cancer cells. Here, we will review some of the more common nanomaterials under investigation and their current and future applications as drug-delivery scaffolds with particular emphasis on targeted cancer radiotherapy. © 2007 Future Medicine Ltd. |
Keywords: |
unclassified drug; acute granulocytic leukemia; review; squamous cell carcinoma; bevacizumab; doxorubicin; nonhuman; drug targeting; paclitaxel; cancer radiotherapy; ibritumomab tiuxetan; rituximab; nuclear magnetic resonance imaging; recurrent cancer; antineoplastic agent; colorectal cancer; unindexed drug; metastasis; breast cancer; lung non small cell cancer; radiotherapy; radiation injury; cetuximab; monoclonal antibodies; panitumumab; b cell lymphoma; t cell lymphoma; nonhodgkin lymphoma; drug accumulation; immunogenicity; drug clearance; forecasting; biocompatibility; nanomedicine; nanoparticle; metastasis potential; drug half life; trastuzumab; gadolinium pentetate; immunosuppressive treatment; radioimmunotherapy; chronic lymphatic leukemia; tositumomab i 131; tissue injury; t cell leukemia; polymer; macrogol; quantum dot; drug conjugation; alemtuzumab; liposome; drug delivery system; liposomes; pentetate indium in 111; head and neck carcinoma; drug carriers; gemtuzumab ozogamicin; skin lymphoma; bystander effect; denileukin diftitox; carbon nanotube; nanomaterial; nanoencapsulation; nanostructures; actinium 225; daclizumab; nanotubes; pentetate technetium tc 99m; α particles; β particles; dendrimers; radioimmunoimaging; 1,4,7,10 tetraazacyclododecane 1,4,7,10 tetraacetic acid in 111; dendrimer; fullerene; nanotube
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