Conscripts of the infinite armada: Systemic cancer therapy using nanomaterials Journal Article
| Authors: | Scheinberg, D. A.; Villa, C. H.; Escorcia, F. E.; McDevitt, M. R. |
| Article Title: | Conscripts of the infinite armada: Systemic cancer therapy using nanomaterials |
| Abstract: | The field of clinical nanomaterials is enlarging steadily, with more than a billion US dollars of funding allocated to research by US government agencies in the past decade. The first generation of anti-cancer agents using novel nanomaterials has successfully entered widespread use. Newer nanomaterials are garnering increasing interest as potential multifunctional therapeutic agents; these drugs are conferred novel properties, by virtue of their size and shape. The new features of these agents could potentially allow increased cancer selectivity, changes in pharmacokinetics, amplification of cytotoxic effects, and simultaneous imaging capabilities. After attachment to cancer target reactive-ligands, which interact with cell-surface antigens or receptors, these new constructs can deliver cytolytic and imaging payloads. The molecules also introduce new challenges for drug development. While nanoscale molecules are of a similar size to proteins, the paradigms for how cells, tissues and organs of the body react to the non-biological materials are not well understood, because most cellular and metabolic processes have evolved to deal with globular, enzyme degradable molecules. We discuss examples of different materials to illustrate interesting principles for development and future applications of these nanomaterial medicines with emphasis on the possible pharmacologic and safety hurdles for accomplishing therapeutic goals. © 2010 Macmillan Publishers Limited. All rights reserved. |
| Keywords: | review; cancer localization; doxorubicin; nonhuman; systemic therapy; antineoplastic agents; drug targeting; antineoplastic agent; neoplasms; animals; gene targeting; diagnostic imaging; cancer therapy; molecular mechanics; regulatory mechanism; forecasting; nanomedicine; toxicity; cell interaction; ligand binding; polymer; macrogol; drug delivery system; particle size; drug solubility; drug manufacture; nervous system neoplasms; carbon nanotube; nanomaterial; molecular size; nanoencapsulation; nanoimaging; nanopharmaceutics; quantum mechanics; surface charge; surface property; tissue interaction; nanostructures |
| Journal Title: | Nature Reviews Clinical Oncology |
| Volume: | 7 |
| Issue: | 5 |
| ISSN: | 1759-4774 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2010-05-01 |
| Start Page: | 266 |
| End Page: | 276 |
| Language: | English |
| DOI: | 10.1038/nrclinonc.2010.38 |
| PUBMED: | 20351700 |
| PROVIDER: | scopus |
| PMCID: | PMC4411965 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 9" - "Export Date: 20 April 2011" - "Source: Scopus" |
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17Escorcia
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