Diagnosis and management of chronic infection Journal Article


Authors: Forsberg, J. A.; Potter, B. K.; Cierny, G. 3rd; Webb, L.
Article Title: Diagnosis and management of chronic infection
Abstract: High-energy penetrating extremity injuries are often associated with severe open fractures that have varying degrees of soft-tissue contamination and tenuous soft-tissue coverage. The result is a relatively high prevalence of chronic osteomyelitis compared with that in civilian trauma patients. Diagnosing chronic osteomyelitis requires a careful history and thorough physical and radiographic examinations. Cross-sectional imaging can help delineate the extent of bony involvement, and scintigraphy can be used as a diagnostic tool and to gauge response to treatment. Clinical staging also directs surgical management. Adequacy of débridement remains the most important clinical predictor of success; thus, adopting an oncologic approach to complete (ie, wide) excision is important. Reconstruction can be safely performed by a variety of methods; however, proper staging and patient selection remain critical to a successful outcome. Although systemic and depot delivery of antibiotics plays a supporting role in the treatment of chronic osteomyelitis, the ideal dosing regimens, and the duration of treatment, remain controversial. Copyright 2011 by the American Academy of Orthopaedic Surgeons.
Keywords: debridement; methodology; classification; diagnostic imaging; chronic disease; hospitalization; antiinfective agent; anti-bacterial agents; severity of illness index; wound infection
Journal Title: Journal of the American Academy of Orthopaedic Surgeons
Volume: 19
Issue: Suppl. 1
ISSN: 1067-151X
Publisher: Lippincott Williams & Wilkins  
Date Published: 2011-01-01
Start Page: S8
End Page: S19
Language: English
PUBMED: 21304049
PROVIDER: scopus
DOI/URL:
Notes: --- - "Export Date: 23 June 2011" - "Source: Scopus"
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