Hepatic metastases from soft-tissue sarcoma Journal Article
| Authors: | Jaques, D. P.; Coit, D. G.; Casper, E. S.; Brennan, M. F. |
| Article Title: | Hepatic metastases from soft-tissue sarcoma |
| Abstract: | Objective: Hepatic metastases from soft-tissue sarcoma are evaluated to define treatment and its limitations. Methods: From 981 adult patients with diagnoses of soft-tissue sarcoma, 65 patients with hepatic metastases were studied. Results: An intra-abdominal primary site was present in 61 of 65 patients, with 85% high grade leiomyosarcoma. Hepatic resection was performed in 14 patients (22%). All patients have had recurrences after hepatic resection-11 of 14 in the liver-with a median survival of 30 months. Chemotherapy resulted in partial response in three patients and no complete responses. Survival is not influenced by grade, type, primary site, disease free interval, chemotherapy, or hepatic resection. Conclusions: The uncommon response to conventional chemotherapy does not support its use in the treatment of hepatic metastases from soft-tissue sarcoma. Extent of disease limits the application and success of hepatic resection for soft-tissue sarcoma, and anything less than complete resection is not indicated. |
| Keywords: | adult; cancer survival; treatment outcome; aged; major clinical study; histopathology; cancer localization; cancer recurrence; doxorubicin; cancer combination chemotherapy; cancer grading; liver metastasis; soft tissue sarcoma; liver resection; leiomyosarcoma; human; male; female; priority journal; article |
| Journal Title: | Annals of Surgery |
| Volume: | 221 |
| Issue: | 4 |
| ISSN: | 0003-4932 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 1995-04-01 |
| Start Page: | 392 |
| End Page: | 397 |
| Language: | English |
| DOI: | 10.1097/00000658-199504000-00010 |
| PUBMED: | 7726675 |
| PROVIDER: | scopus |
| PMCID: | PMC1234589 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 28 August 2018 -- Source: Scopus |
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