Regulation of translation and cancer Journal Article


Author: Holland, E. C.
Article Title: Regulation of translation and cancer
Abstract: One of the effects of oncogenic signaling appears to be differentiated recruitment of mRNA's to ribosomes. The mRNA's so affected frequently encode proteins involved in growth regulation cell-cell interaction. These functions are critical for both cancer and development, potentially suggesting that the normal role of differential translation may be during development. It is not known whether this effect is sufficient to induce cancer from cells with an initial non-neoplastic gene expression profile.
Keywords: translation; tumor; cyclin d1; malignant transformation; cell-growth; mammalian target; suppression; initiation-factor 4e; lhermitte-duclos-disease; oncogenic signaling; cancer; ribosome recruitment; ribosomal-protein s6; messenger-rna subsets; amino-acid-transport
Journal Title: Cell Cycle
Volume: 3
Issue: 4
ISSN: 1538-4101
Publisher: Taylor & Francis Inc.  
Date Published: 2004-04-01
Start Page: 452
End Page: 455
Language: English
ACCESSION: WOS:000222361700021
PROVIDER: wos
DOI: 10.4161/cc.3.4.796
Notes: Review -- Source: Wos
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