FibroSURE as a noninvasive marker of liver fibrosis and inflammation in chronic hepatitis B Journal Article
| Authors: | Zeremski, M.; Dimova, R. B.; Benjamin, S.; Makeyeva, J.; Yantiss, R. K.; Gambarin-Gelwan, M.; Talal, A. H. |
| Article Title: | FibroSURE as a noninvasive marker of liver fibrosis and inflammation in chronic hepatitis B |
| Abstract: | Background: Noninvasive markers of liver fibrosis have not been extensively studied in patients with chronic hepatitis B virus (HBV) infection. Our aim was to evaluate the capacity of FibroSURE, one of the two noninvasive fibrosis indices commercially available in the United States, to identify HBV infected patients with moderate to severe fibrosis.Methods: Forty-five patients who underwent liver biopsy at a single tertiary care center were prospectively enrolled and had FibroSURE performed within an average interval of 11 days of the biopsy.Results: Of the 45 patients, 40% were Asian, 40% were African American, and 13% were Caucasian; 27% were co-infected with HIV and 67% had no or mild fibrosis. We found FibroSURE to have moderate capacity to discriminate between patients with moderate to high fibrosis and those with no to mild fibrosis (area under receiver operating characteristic [AUROC] curve = 0.77; 95% confidence interval [CI] [0.61, 0.92]). When we combined the fibrosis score determined by FibroSURE with aspartate aminotransferase (AST) measurements and HIV co-infection status, the discriminatory ability significantly improved reaching an AUROC of 0.90 (95% CI [0.80, 1.00]). FibroSURE also had a good ability to differentiate patients with no or mild from those with moderate to high inflammation (AUROC = 0.83; 95% CI [0.71, 0.95]).Conclusions: FibroSURE in combination with AST levels has an excellent capacity to identify moderate to high fibrosis stages in chronic HBV-infected patients. These data suggest that FibroSURE may be a useful substitute for liver biopsy in chronic HBV infection. © 2014 Zeremski et al.; licensee BioMed Central Ltd. |
| Keywords: | adult; clinical article; controlled study; human tissue; hepatitis b; human immunodeficiency virus infection; prospective study; sensitivity and specificity; aspartate aminotransferase; disease severity; hepatitis b virus; liver biopsy; african american; predictive value; caucasian; receiver operating characteristic; lamivudine; asian; diagnostic test accuracy study; liver fibrosis; entecavir; tenofovir; mixed infection; liver histology; human; male; female; article; liver biopsy replacement; liver fibrosis assessment; emtricitabine plus tenofovir disoproxil; liver function test kit |
| Journal Title: | BMC Gastroenterology |
| Volume: | 14 |
| Issue: | 1 |
| ISSN: | 1471-230X |
| Publisher: | Biomed Central Ltd |
| Date Published: | 2014-07-03 |
| Start Page: | 118 |
| Language: | English |
| DOI: | 10.1186/1471-230x-14-118 |
| PROVIDER: | scopus |
| PMCID: | PMC4086988 |
| PUBMED: | 24990385 |
| DOI/URL: | |
| Notes: | Export Date: 1 August 2014 -- CODEN: BGMAB -- Source: Scopus |
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