Hepatitis B virus infection and hepatocellular carcinoma in PLWH: Epidemiology, pathogenesis and treatment Review
| Authors: | D'Andrea, F.; Venanzi Rullo, E.; Marino, A.; Moscatt, V.; Celesia, B. M.; Cacopardo, B.; Condorelli, F.; La Rocca, G.; Di Rosa, M.; Pellicano, G. F.; Nunnari, G.; Ceccarelli, M. |
| Review Title: | Hepatitis B virus infection and hepatocellular carcinoma in PLWH: Epidemiology, pathogenesis and treatment |
| Abstract: | Combined Antiretroviral therapy altered the natural history of Human Immunodeficiency Virus (HIV) infection, leading to a substantial decline in morbidity and mortality of patients living with HIV. Due to the shared transmission routes, co-infection with HBV and HIV is not uncommon, especially in those patients with similar socioeconomic vulnerabilities and psycho-social conditions. HBV is a known cause of HCC even in absence of cirrhosis, and HIV-HBV-coinfected patients may have faster progression of hepatic fibrosis and a higher risk of cirrhosis and consequently HCC. In this article we review the epidemiology, the etiology, the role of coinfection HIV/HBV in the pathogenesis of liver cancer, the management and prevention of HBV infection in HIV-infected patients in the era of combined antiretroviral treatment. |
| Keywords: | liver; hiv; cells; disease; kaposis-sarcoma; malignancies; hcc; viral clearance; therapeutic management; coinfection; cancer; pregnant-women; hbv; b hepatitis |
| Journal Title: | World Cancer Research Journal |
| Volume: | 7 |
| ISSN: | 2372-3416 |
| Publisher: | Verduci Publisher |
| Date Published: | 2020-01-01 |
| Start Page: | e1537 |
| Language: | English |
| ACCESSION: | WOS:000518444400001 |
| PROVIDER: | wos |
| DOI: | 10.32113/wcrj_20203_1537 |
| Notes: | Article -- Source: Wos |
