Localization of retrovirus in the central nervous system of a patient co-infected with HTLV-1 and HIV with HAM/TSP and HIV-associated dementia Journal Article
| Authors: | Levin, M. C.; Rosenblum, M. K.; Fox, C. H.; Jacobson, S. |
| Article Title: | Localization of retrovirus in the central nervous system of a patient co-infected with HTLV-1 and HIV with HAM/TSP and HIV-associated dementia |
| Abstract: | Persons co-infected with HTLV-1 and HIV are at increased risk for neurologic disease. These patients may develop HAM/TSP and/or HIV-associated dementia. In this study, we localized cells infected with retrovirus in the central nervous system (CNS) of a patient with both HAM/TSP and HIV associated dementia. HTLV-1 was localized to astrocytes and HIV to macrophage/microglia. There was no co-infection of a single cell phenotype in this patient. These data suggest that mechanisms other than co-infection of the same CNS cell may play a role in the development of neurologic disease in patients dual infected with HTLV-1 and HIV. |
| Keywords: | lymphocytes; neurologic disease; hiv; expression; myelopathy; virus type-i; situ hybridization; htlv-1; hiv-associated dementia; ham/tsp |
| Journal Title: | Journal of Neurovirology |
| Volume: | 7 |
| Issue: | 1 |
| ISSN: | 1355-0284 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2001-01-01 |
| Start Page: | 61 |
| End Page: | 65 |
| Language: | English |
| ACCESSION: | WOS:000170997600009 |
| PROVIDER: | wos |
| PUBMED: | 11519484 |
| DOI: | 10.1080/135502801300069719 |
| Notes: | Article -- Source: Wos |
