Dissociation of AIDS-related vacuolar myelopathy and productive HIV-1 infection of the spinal cord Journal Article

  


Authors: Rosenblum, M.; Scheck, A. C.; Cronin, K.; Brew, B. J.; Khan, A.; Paul, M.; Price, R. W.
Article Title: Dissociation of AIDS-related vacuolar myelopathy and productive HIV-1 infection of the spinal cord
Abstract: Although merging clinically within the spectrum of the AIDS dementia complex, vacuolar myelopathy is a pathologically distinct entity detected in up to 30% of autopsied patients succumbing to the late complications of human immunodeficiency virus type 1 (HIV-1) infection. Using immunohistochemistry and in situ hybridization to detect an HIV-1 core protein and viral mRNA, respectively, in tissue sections, and culture isolation to asaess infectious virus in tissue homogenates, we found that vacuolar myelopathy was independent of productive HIV-1 infection of the spinal cord and brain. These results indicate that AIDS-associated vacuolar myelopathy is either not related directly to spinal cord HIV-1 infection or involves nonproductive infection and pathobiological processes distinct from those responsible for the multinucleated-cell inflammatory infiltrates that serve as histopathologic markers of productive CNS HIV-1 infection. © 1989 American Academy of Neurology.
Keywords: immunohistochemistry; clinical article; human immunodeficiency virus infection; genetic engineering; brain; rna, messenger; spinal cord; histochemistry; acquired immune deficiency syndrome; acquired immunodeficiency syndrome; nucleic acid hybridization; autopsy; encephalitis; rna, viral; spinal cord disease; human immunodeficiency virus 1; hiv-1; spinal cord diseases; vacuoles; human; priority journal; support, non-u.s. gov't; support, u.s. gov't, p.h.s.
Journal Title: Neurology
Volume: 39
Issue: 7
ISSN: 0028-3878
Publisher: Lippincott Williams & Wilkins  
Date Published: 1989-07-01
Start Page: 892
End Page: 896
Language: English
PUBMED: 2739916
PROVIDER: scopus
DOI: 10.1212/wnl.39.7.892
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024321846&partnerID=40&md5=90bc3ef56e7b6bd17080b56553a02175
Notes: Article -- Export Date: 14 April 2020 -- Source: Scopus
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MSK Authors
  1. Marc Rosenblum
    424 Rosenblum
  2. Richard W. Price
    58 Price
  3. Bruce J. Brew
    19 Brew
  4. Kathryn C. Cronin
    14 Cronin
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