Can we predict response and/or resistance to neoadjuvant chemoradiotherapy in patients with rectal cancer? Journal Article

  


Authors: Chow, O.S.; Smith, J. J.; Gollub, M. J.; Garcia-Aguilar, J.
Article Title: Can we predict response and/or resistance to neoadjuvant chemoradiotherapy in patients with rectal cancer?
Abstract: The current management of locally advanced rectal cancer consists of neoadjuvant chemoradiotherapy (CRT) followed by total mesorectal excision. Response to CRT varies significantly, and the ability to predict responsiveness, so that treatment modalities can be tailored to the tumor biology of the individual patient, remains a pressing goal. Although many studies have reported promising findings, no markers of response or resistance have been validated and widely incorporated into clinical use. However, many ongoing prospective clinical trials have the potential to dramatically change the standard of care for rectal cancer. This review summarizes the current understanding of predictors of response to CRT, ranging from patient-specific factors to radiologic modalities, with a special emphasis on the rapidly expanding field of molecular biomarkers derived from genomic data. © 2014 Springer Science+Business Media New York.
Keywords: treatment response; gene mutation; advanced cancer; multimodality cancer therapy; cancer patient; combined modality therapy; prospective study; biomarkers; microrna; gene expression; gene expression profiling; tumor regression; validation study; chemosensitivity; cancer resistance; molecular marker; health care quality; genomic instability; genomics; radiosensitivity; micrornas; rectum cancer; meta analysis; ras; p53; rectal cancer; dna polymorphism; clinical trial (topic); treatment protocols; pathologic complete response; single-nucleotide polymorphisms; neoadjuvant chemoradiotherapy; adjuvant chemoradiotherapy; gene mutations; human; article; high-throughput sequencing
Journal Title: Current Colorectal Cancer Reports
Volume: 10
Issue: 2
ISSN: 1556-3790
Publisher: Springer  
Date Published: 2014-06-01
Start Page: 164
End Page: 172
Language: English
DOI: 10.1007/s11888-014-0210-0
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84903742767&partnerID=40&md5=1da091ac48c511327eebfc1d5433fb4e
Notes: Export Date: 1 August 2014 -- Source: Scopus
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MSK Authors
  1. Marc J Gollub
    208 Gollub
  2. Julio Garcia Aguilar
    347 Garcia Aguilar
  3. Jesse Joshua Smith
    217 Smith
  4. Oliver Chow
    20 Chow
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