Non-operative management of locally advanced rectal cancer Journal Article
| Authors: | Milgrom, S. A.; Goodman, K. A. |
| Article Title: | Non-operative management of locally advanced rectal cancer |
| Abstract: | A combination of chemoradiation therapy (CRT) and total mesorectal excision (TME) provides excellent locoregional control in locally advanced rectal cancer; however, this regimen may be associated with significant morbidity. Researchers have assessed the safety of omitting rectal resection in patients who achieve a clinical complete response to CRT. Preliminary results have been promising. However, the accurate identification of patients who have responded completely to CRT is a challenge to non-operative management. Other areas warranting further investigation include techniques to increase response rates and to identify upfront those patients who are most likely to respond to CRT. © 2014 Elsevier Inc. |
| Keywords: | cancer chemotherapy; treatment response; overall survival; advanced cancer; cancer adjuvant therapy; disease free survival; nuclear magnetic resonance imaging; progression free survival; morbidity; carcinoembryonic antigen; cohort analysis; antigen detection; brachytherapy; physical examination; external beam radiotherapy; endoscopy; rectum cancer; digital rectal examination; rectoscopy; human; article |
| Journal Title: | Seminars in Colon and Rectal Surgery |
| Volume: | 25 |
| Issue: | 1 |
| ISSN: | 1043-1489 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2014-03-01 |
| Start Page: | 22 |
| End Page: | 25 |
| Language: | English |
| DOI: | 10.1053/j.scrs.2013.09.006 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 3 March 2014 -- CODEN: SCRSF -- Source: Scopus |
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