Is gastric cancer different in Korea and the United States? Impact of tumor location on prognosis Journal Article


Authors: Shim, J. H.; Song, K. Y.; Jeon, H. M.; Park, C. H.; Jacks, L. M.; Gonen, M.; Shah, M. A.; Brennan, M. F.; Coit, D. G.; Strong, V. E.
Article Title: Is gastric cancer different in Korea and the United States? Impact of tumor location on prognosis
Abstract: Purpose: To compare the characteristics and prognoses of gastric cancers by tumor location in Korean and U.S. subjects after curative-intent (R0) resection for gastric cancer (GC). Methods: Data were collected for all patients who had undergone R0 resection at one U.S. institution (n = 567) and one South Korean institution (n = 1,620). Patients with gastroesophageal junction tumors or neoadjuvant therapy were excluded. Patient, surgical, and pathologic variables were compared by tumor location. Factors associated with disease-specific survival (DSS) were determined via multivariate analysis. Results: In the Korean cohort, significantly more upper third GC (UTG) patients had undifferentiated, diffuse type, and advanced stage cancers compared to lower third GC (LTG) and middle third GC (MTG) patients. In the U.S. cohort, however, T stage was relatively evenly distributed among UTG, MTG, and LTG patients. The independent predictors of DSS in the Korean cohort were T stage, tumor size, retrieved and positive lymph node counts, and age, but in the U.S. cohort, the only independent predictors were T stage and positive lymph node count. Tumor size significantly affected DSS of Korean UTG patients but not U.S. UTG patients. Conclusions: There were significant differences in tumor characteristics by tumor location within and between both national cohorts. On the basis of these findings, further study to investigate the biological difference between the two countries is needed. © 2014 Society of Surgical Oncology.
Keywords: adult; cancer survival; controlled study; human tissue; aged; major clinical study; cancer localization; united states; cancer patient; cancer staging; lymph node metastasis; lymph node dissection; lymph node; cancer size; gastrectomy; stomach cancer; korea; cancer prognosis; human; male; female; article
Journal Title: Annals of Surgical Oncology
Volume: 21
Issue: 7
ISSN: 1068-9265
Publisher: Springer  
Date Published: 2014-07-01
Start Page: 2332
End Page: 2339
Language: English
DOI: 10.1245/s10434-014-3608-7
PROVIDER: scopus
DOI/URL:
Notes: Ann. Surg. Oncol. -- Export Date: 8 July 2014 -- CODEN: ASONF -- Source: Scopus
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MSK Authors
  1. Murray F Brennan
    791 Brennan
  2. Mithat Gonen
    726 Gonen
  3. Vivian Strong
    148 Strong
  4. Daniel Coit
    427 Coit
  5. Lindsay Jacks
    37 Jacks