Comparison of gastric cancer survival after R0 resection in the US and China Journal Article


Authors: Li, P.; Huang, C. M.; Zheng, C. H.; Russo, A.; Kasbekar, P.; Brennan, M. F.; Coit, D. G.; Strong, V. E.
Article Title: Comparison of gastric cancer survival after R0 resection in the US and China
Abstract: Background and Objectives: Gastric cancer (GC) outcomes differ between Asian and Western countries, even when controlling for contributing factors, but whether this difference holds true for China remains inadequately studied. We sought to compare the presentation, treatment, and outcomes of patients with GC undergoing curative intent (R0) resection between the US and China, and to ascertain whether geography/ institution is an independent predictor of disease-specific survival (DSS). Methods: Data were analyzed from patients with GC undergoing R0 resection at high-volume cancer centers in the US (Memorial Sloan Kettering Cancer Center [MSKCC], n = 1378) and China (Fujian Medical University Union Hospital [FMUUH], n = 4262) between 2000 and 2014. Factors associated with DSS were examined by multivariate analysis. Results: The 5-year DSS (P < 0.001) for all patients was better at MSKCC than at FMUUH, even among patients not receiving preoperative chemotherapy (P < 0.001), but stratification by substage eliminated this difference (P > 0.05). Factors independently associated with DSS included age, histology, tumor size, T category, N category, gastrectomy type, and preoperative chemotherapy, but not institution. Conclusions: Although the presentation of patients with GC between MSKCC and FMUUH differs, survival of patients with curatively resected GC, when matched for clinical stage, is comparable. © 2018 Wiley Periodicals, Inc.
Keywords: united states; stomach cancer; perioperative chemotherapy; stomach neoplasms; china; eastern and western; prognosis
Journal Title: Journal of Surgical Oncology
Volume: 118
Issue: 6
ISSN: 0022-4790
Publisher: Wiley Blackwell  
Date Published: 2018-11-01
Start Page: 975
End Page: 982
Language: English
DOI: 10.1002/jso.25220
PUBMED: 30332517
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 3 December 2018 -- Source: Scopus
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MSK Authors
  1. Murray F Brennan
    779 Brennan
  2. Vivian Strong
    148 Strong
  3. Daniel Coit
    421 Coit
  4. Ashley Elizabeth Russo
    8 Russo