Comparison of disease-specific survival in the United States and Korea after resection for early-stage node-negative gastric carcinoma Journal Article


Authors: Strong, V. E.; Song, K. Y.; Park, C. H.; Jacks, L. M.; Gonen, M.; Shah, M. A.; Coit, D. G.; Brennan, M. F.
Article Title: Comparison of disease-specific survival in the United States and Korea after resection for early-stage node-negative gastric carcinoma
Abstract: Background and Objectives Disease-specific survival (DSS) for GC patients differs in Eastern and Western countries. The aim is to compare outcomes of US and Korean patients following resection of early-stage, node-negative gastric carcinoma (GC). Methods All patients (1995-2005) with T1N0 gastric carcinoma, excluding gastroesophageal tumors, were evaluated. DSS was compared by adjusting for prognostic variables from an internationally validated GC nomogram. Results The cohort included 598 Korean patients and 159 US patients. Age and BMI were significantly higher in US patients. Distal tumor location was more frequent in Korea (60% vs. 52%) and proximal location in the US (19% vs. 5%, P < 0.0001). Five-year DSS did not differ significantly between Korea and the US. After multivariate analysis, DSS of Korean patients persisted, with no significant differences when compared to US patients (HR = 1.2, 95% CI: 0.3-5.2, P = 0.83). Conclusions Despite widespread speculations that GC differs in the East and West, when we compare similarly staged, node-negative GC patients, survival did not differ significantly between Korea and the US. This suggests that GC is a heterogeneous disease and when similar subtypes of gastric cancer are compared, these differences disappear. This study suggests more similarities than previously hypothesized between US and Korean GC patients. © 2012 Wiley Periodicals, Inc.
Keywords: gastric carcinoma; early gastric cancer; eastern and western
Journal Title: Journal of Surgical Oncology
Volume: 107
Issue: 6
ISSN: 0022-4790
Publisher: Wiley Blackwell  
Date Published: 2013-05-01
Start Page: 634
End Page: 640
Language: English
PROVIDER: scopus
PUBMED: 23192297
DOI: 10.1002/jso.23288
PMCID: PMC4180518
DOI/URL:
Notes: --- - "Export Date: 1 May 2013" - "CODEN: JSONA" - ":doi 10.1002/jso.23288" - "Source: Scopus"
Altmetric
Citation Impact
MSK Authors
  1. Murray F Brennan
    980 Brennan
  2. Mithat Gonen
    824 Gonen
  3. Kyo Young Song
    3 Song
  4. Manish Shah
    177 Shah
  5. Vivian Strong
    189 Strong
  6. Daniel Coit
    495 Coit
  7. Lindsay Jacks
    37 Jacks