Lobular neoplasia Journal Article
| Authors: | King, T. A.; Reis-Filho, J. S. |
| Article Title: | Lobular neoplasia |
| Abstract: | Lobular neoplasia (LN) is characterized by a dysfunctional E-cadherin-catenin axis, and loss of E-cadherin plays a causative role in the typical morphology of LN cells. LN is both a nonobligate precursor and a risk indicator of invasive breast cancer, and in particular, of invasive lobular carcinoma. Despite the evidence supporting the precursor role of LN, its impact on clinical management has been a matter of controversy, and conservative management remains the mainstay of treatment. In this article, an update is provided on the pathology and genetics of LN, and the management of these lesions in surgical practice is discussed. © 2014 Elsevier Inc. |
| Keywords: | signal transduction; cancer chemotherapy; protein expression; methylation; single nucleotide polymorphism; gene deletion; clinical feature; review; placebo; cancer risk; disease classification; nonhuman; protein function; phenotype; cancer prevention; chemoprophylaxis; breast cancer; mastectomy; epidermal growth factor receptor 2; transcriptomics; protein p53; uvomorulin; exemestane; pathological anatomy; breast tumor; breast carcinoma; needle biopsy; tamoxifen; gene loss; cancer epidemiology; progesterone receptor; risk reduction; tumor gene; comparative genomic hybridization; intraductal carcinoma; e-cadherin; lobular carcinoma in situ; lobular neoplasia; raloxifene; disease surveillance; atypical lobular hyperplasia; breast cancer risk; breast hyperplasia; chemoprevention; core needle biopsy; estrogen receptor alpha; her2 gene; estrogen receptor beta; human |
| Journal Title: | Surgical Oncology Clinics of North America |
| Volume: | 23 |
| Issue: | 3 |
| ISSN: | 1055-3207 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2014-07-01 |
| Start Page: | 487 |
| End Page: | 503 |
| Language: | English |
| DOI: | 10.1016/j.soc.2014.03.002 |
| PROVIDER: | scopus |
| PUBMED: | 24882347 |
| DOI/URL: | |
| Notes: | Surg. Oncol. Clin. North Am. -- Export Date: 8 July 2014 -- CODEN: SOCAF -- Source: Scopus |
