Nucleocytoplasmic shuttling of signal transducers Journal Article
| Authors: | Xu, L.; Massagué, J. |
| Article Title: | Nucleocytoplasmic shuttling of signal transducers |
| Abstract: | The nuclear translocation of signal-transduction proteins is an essential step in the control of gene expression by numerous extracellular signals. Recent studies have shown that some signal transducers are imported into the nucleus by nuclear-localization-signal- and importin-independent processes. Such a mechanism could allow bidirectional movement across the nuclear envelope. Extracellular signals modify the affinity between signal transducers and anchoring factors, thereby regulating the nucleocytoplasmic shuttling of signalling molecules. |
| Keywords: | signal transduction; mitogen activated protein kinase; review; animals; models, biological; transforming growth factor beta; molecular dynamics; genetic transcription; molecular mechanics; gene expression regulation; nucleocytoplasmic transport; regulatory mechanism; gene disruption; cytoplasm; active transport, cell nucleus; cell nucleus; porosity; wnt protein; nuclear localization signal; biological transport; transport kinetics; karyopherins; humans; priority journal; karyopherin |
| Journal Title: | Nature Reviews Molecular Cell Biology |
| Volume: | 5 |
| Issue: | 3 |
| ISSN: | 1471-0072 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2004-03-01 |
| Start Page: | 209 |
| End Page: | 219 |
| Language: | English |
| DOI: | 10.1038/nrm1331 |
| PROVIDER: | scopus |
| PUBMED: | 14991001 |
| DOI/URL: | |
| Notes: | Nat. Rev. Mol. Cell Biol. -- Cited By (since 1996):148 -- Export Date: 16 June 2014 -- CODEN: NRMCB -- Source: Scopus |
