Signal processing in the TGF-β superfamily ligand-receptor network Journal Article
| Authors: | Vilar, J. M. G.; Jansen, R.; Sander, C. |
| Article Title: | Signal processing in the TGF-β superfamily ligand-receptor network |
| Abstract: | The TGF-β pathway plays a central role in tissue homeostasis and morphogenesis. It transduces a variety of extracellular signals into intracellular transcriptional responses that control a plethora of cellular processes, including cell growth, apoptosis, and differentiation. We use computational modeling to show that coupling of signaling with receptor trafficking results in a highly versatile signal-processing unit, able to sense by itself absolute levels of ligand, temporal changes in ligand concentration, and ratios of multiple ligands. This coupling controls whether the response of the receptor module is transient or permanent and whether or not different signaling channels behave independently of each other. Our computational approach unifies seemingly disparate experimental observations and suggests specific changes in receptor trafficking patterns that can lead to phenotypes that favor tumor progression. Copyright: © 2006 Vilar et al. |
| Keywords: | signal transduction; phenotype; complex formation; cell growth; transforming growth factor beta; mathematical model; transcription regulation; ligand; tumor growth; protein family; concentration (parameters); receptor binding; experimentation |
| Journal Title: | PLoS Computational Biology |
| Volume: | 2 |
| Issue: | 1 |
| ISSN: | 1553-7358 |
| Publisher: | Public Library of Science |
| Date Published: | 2006-01-01 |
| Start Page: | 0036 |
| End Page: | 0045 |
| Language: | English |
| DOI: | 10.1371/journal.pcbi.0020003 |
| PROVIDER: | scopus |
| PMCID: | PMC1356091 |
| PUBMED: | 16446785 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 41" - "Export Date: 4 June 2012" - "Source: Scopus" |
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