Perspectives for computer modeling in the study of T cell activation Journal Article
| Authors: | Coward, J.; Germain, R. N.; Altan-Bonnet, G. |
| Article Title: | Perspectives for computer modeling in the study of T cell activation |
| Abstract: | The T cell receptor (TCR) is responsible for discriminating between self- and foreign-derived peptides, translating minute differences in amino-acid sequence into large differences in response. Because of the great variability in the TCR and its ligands, activation of T cells by foreign peptides is a quantitative process, dependent on a mix of upstream signals and downstream integration. Accordingly, quantitative data and computational models have shed light on many important aspects of this process: molecular noise in ligand recognition, spatial dynamics in T cell-APC (antigen presenting cell) interactions, graded versus all-or-none decision making by the TCR apparatus, mechanisms of peptide antagonism and synergism, and the tunability and robustness of activation thresholds. Though diverse in their formalism, these studies together paint a picture of how modeling has shaped and will continue to shape understanding of T cell immunobiology. |
| Keywords: | signal transduction; review; t lymphocyte; t-lymphocytes; biological model; models, biological; physiology; lymphocyte activation; computer simulation |
| Journal Title: | Cold Spring Harbor Perspectives in Medicine |
| Volume: | 2 |
| Issue: | 6 |
| ISSN: | 2157-1422 |
| Publisher: | Cold Spring Harbor Laboratory Press |
| Date Published: | 2010-06-01 |
| Start Page: | a005538 |
| Language: | English |
| DOI: | 10.1101/cshperspect.a005538 |
| PUBMED: | 20516137 |
| PROVIDER: | scopus |
| PMCID: | PMC2869519 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "Source: Scopus" |
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