Strength of TCR-peptide/MHC interactions and in vivo T cell responses Journal Article
| Authors: | Corse, E.; Gottschalk, R. A.; Allison, J. P. |
| Article Title: | Strength of TCR-peptide/MHC interactions and in vivo T cell responses |
| Abstract: | The TCR can detect subtle differences in the strength of interaction with peptide/MHC ligand and transmit this information to influence downstream events in T cell responses. Manipulation of the factor commonly referred to as TCR signal strength can be achieved by changing the amount or quality of peptide/MHC ligand. Recent work has enhanced our understanding of the many variables that contribute to the apparent cumulative strength of TCR stimulation during immunogenic and tolerogenic T cell responses. In this review, we consider data fromin vitro studies in the context of in vivo immune responses and discuss in vivo consequences of manipulation of strength of TCR stimulation, including influences on T cell-APC interactions, the magnitude and quality of the T cell response, and the types of fate decisions made by peripheral T cells. Copyright © 2011 by The American Association of Immunologists, Inc. |
| Keywords: | cancer survival; drug dose comparison; drug efficacy; nonhuman; disease free survival; drug megadose; binding affinity; transcription factor foxp3; cd8+ t lymphocyte; lymphocyte proliferation; complex formation; low drug dose; interleukin 4; cell fate; in vivo study; drug potency; in vitro study; drug receptor binding; lymphocyte differentiation; t lymphocyte receptor; immunological tolerance; cancer immunization; cd4+ t lymphocyte; malignant neoplastic disease; short survey; cytokine production; effector cell; adaptive immunity; cell interaction; ligand binding; antigen presenting cell; t lymphocyte activation; listeria monocytogenes; peripheral lymphocyte; major histocompatibility antigen; cell manipulation |
| Journal Title: | Journal of Immunology |
| Volume: | 186 |
| Issue: | 9 |
| ISSN: | 0022-1767 |
| Publisher: | The American Association of Immunologists, Inc |
| Date Published: | 2011-05-01 |
| Start Page: | 5039 |
| End Page: | 5045 |
| Language: | English |
| DOI: | 10.4049/jimmunol.1003650 |
| PROVIDER: | scopus |
| PUBMED: | 21505216 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 23 June 2011" - "CODEN: JOIMA" - "Source: Scopus" |
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