The ABCs of artificial antigen presentation Journal Article
| Authors: | Kim, J.; Latouche, J. B.; Riviere, I.; Sadelain, M. |
| Article Title: | The ABCs of artificial antigen presentation |
| Abstract: | Artificial antigen presentation aims to accelerate the establishment of therapeutic cellular immunity. Artificial antigen-presenting cells (AAPCs) and their cell-free substitutes are designed to stimulate the expansion and acquisition of optimal therapeutic features of T cells before therapeutic infusion, without the need for autologous antigen-presenting cells. Compelling recent advances include fibroblast AAPCs that process antigens, magnetic beads that are antigen specific, novel T-cell costimulatory combinations, the augmentation of therapeutic potency of adoptively transferred T lymphocytes by interleukin-15, and the safe use of dendritic cell-derived exosomes pulsed with tumor antigen. Whereas the safety and potency of the various systems warrant further preclinical and clinical studies, these emerging technologies are poised to have a major impact on adoptive T-cell therapy and the investigation of T cell-mediated immunity. |
| Keywords: | human cell; review; nonhuman; cd3 antigen; cd8 antigen; t lymphocyte; t-lymphocytes; animal cell; animals; mice; immune system; models, biological; dendritic cell; biotechnology; animalia; t lymphocyte receptor; cytokine; antigen presentation; immunology; dendritic cells; cellular immunity; chemokine; immunotherapy; antigens; cancer vaccines; tumors; hla antigen class 2; cytotoxic t lymphocyte; hla antigen class 1; vaccines, synthetic; fibroblast; fibroblasts; drosophila melanogaster; cd4 antigen; drug therapy; major histocompatibility complex; antigen presenting cell; t lymphocyte subpopulation; antigen-presenting cells; cd28 antigen; liposome; liposomes; hla system; magnetics; cells; insects; major histocompatibility antigen; interleukin-15; melanogaster; cell-free system; cd32 antigen; humans; human; priority journal; artificial antigen presentation |
| Journal Title: | Nature Biotechnology |
| Volume: | 22 |
| Issue: | 4 |
| ISSN: | 1087-0156 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2004-04-01 |
| Start Page: | 403 |
| End Page: | 410 |
| Language: | English |
| DOI: | 10.1038/nbt955 |
| PROVIDER: | scopus |
| PUBMED: | 15060556 |
| DOI/URL: | |
| Notes: | Nat. Biotechnol. -- Cited By (since 1996):71 -- Export Date: 16 June 2014 -- CODEN: NABIF -- Source: Scopus |
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