The ABCs of artificial antigen presentation Journal Article


Authors: Kim, J.; Latouche, J. B.; Riviere, I.; Sadelain, M.
Article Title: The ABCs of artificial antigen presentation
Abstract: Artificial antigen presentation aims to accelerate the establishment of therapeutic cellular immunity. Artificial antigen-presenting cells (AAPCs) and their cell-free substitutes are designed to stimulate the expansion and acquisition of optimal therapeutic features of T cells before therapeutic infusion, without the need for autologous antigen-presenting cells. Compelling recent advances include fibroblast AAPCs that process antigens, magnetic beads that are antigen specific, novel T-cell costimulatory combinations, the augmentation of therapeutic potency of adoptively transferred T lymphocytes by interleukin-15, and the safe use of dendritic cell-derived exosomes pulsed with tumor antigen. Whereas the safety and potency of the various systems warrant further preclinical and clinical studies, these emerging technologies are poised to have a major impact on adoptive T-cell therapy and the investigation of T cell-mediated immunity.
Keywords: human cell; review; nonhuman; cd3 antigen; cd8 antigen; t lymphocyte; t-lymphocytes; animal cell; animals; mice; immune system; models, biological; dendritic cell; biotechnology; animalia; t lymphocyte receptor; cytokine; antigen presentation; immunology; dendritic cells; cellular immunity; chemokine; immunotherapy; antigens; cancer vaccines; tumors; hla antigen class 2; cytotoxic t lymphocyte; hla antigen class 1; vaccines, synthetic; fibroblast; fibroblasts; drosophila melanogaster; cd4 antigen; drug therapy; major histocompatibility complex; antigen presenting cell; t lymphocyte subpopulation; antigen-presenting cells; cd28 antigen; liposome; liposomes; hla system; magnetics; cells; insects; major histocompatibility antigen; interleukin-15; melanogaster; cell-free system; cd32 antigen; humans; human; priority journal; artificial antigen presentation
Journal Title: Nature Biotechnology
Volume: 22
Issue: 4
ISSN: 1087-0156
Publisher: Nature Publishing Group  
Date Published: 2004-04-01
Start Page: 403
End Page: 410
Language: English
DOI: 10.1038/nbt955
PROVIDER: scopus
PUBMED: 15060556
DOI/URL:
Notes: Nat. Biotechnol. -- Cited By (since 1996):71 -- Export Date: 16 June 2014 -- CODEN: NABIF -- Source: Scopus
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MSK Authors
  1. Jiyun Kim
    1 Kim
  2. Michel W J Sadelain
    462 Sadelain
  3. Isabelle C Riviere
    168 Riviere