Dendritic cells and immunotherapy for cancer Journal Article
| Authors: | Chang, D. H.; Dhodapkar, M. V. |
| Article Title: | Dendritic cells and immunotherapy for cancer |
| Abstract: | Dendritic cells, nature's adjuvant, are antigen-presenting cells specialized to initiate and regulate immunity. Their potent antigen-presenting function has encouraged targeting of dendritic cells (DCs) for harnessing the immune system against cancer. DCs are efficient at activating not only CD4+ helper T-cells and CD8+ killer T-cells but also B-cells and innate effectors such as natural killer and natural killer T-cells. Early studies of adoptive transfer of tumor antigen-loaded DCs have shown promise. However, DC vaccination is at an early stage, and several parameters still need to be established. The complexity of the DC system brings about the necessity for its rational manipulation for achieving protective and therapeutic immunity in patients. © 2003 The Japanese Society of Hematology. |
| Keywords: | review; nonhuman; dendritic cell; b lymphocyte; immunoregulation; antigen presentation; dendritic cells; immunotherapy; cancer vaccines; cytotoxic t lymphocyte; natural killer cell; tumor vaccine; adoptive immunotherapy; antigen presenting cell; t lymphocyte subpopulation; immunotherapy, adoptive; helper cell; t-cells; cancer; humans; human |
| Journal Title: | International Journal of Hematology |
| Volume: | 77 |
| Issue: | 5 |
| ISSN: | 0925-5710 |
| Publisher: | Springer Japan KK |
| Date Published: | 2003-06-01 |
| Start Page: | 439 |
| End Page: | 443 |
| Language: | English |
| PUBMED: | 12841381 |
| PROVIDER: | scopus |
| DOI: | 10.1007/BF02986611 |
| DOI/URL: | |
| Notes: | Export Date: 25 September 2014 -- Source: Scopus |
