Single injection of CD34+ progenitor-derived dendritic cell vaccine can lead to induction of T-cell immunity in patients with stage IV melanoma Journal Article
| Authors: | Palucka, A. K.; Dhodapkar, M. V.; Paczesny, S.; Burkeholder, S.; Wittkowski, K. M.; Steinman, R. M.; Fay, J.; Banchereau, J. |
| Article Title: | Single injection of CD34+ progenitor-derived dendritic cell vaccine can lead to induction of T-cell immunity in patients with stage IV melanoma |
| Abstract: | There is evidence that dendritic cell (DC) vaccines induce tumor-specific immune responses that correlate with clinical responses. Little is known, however, about the kinetics of T-cell responses to antigens presented on DC vaccines. The authors vaccinated 18 HLA A*0201+ patients with stage IV melanoma with CD34 HPC-derived DCs pulsed with six antigens: influenza matrix peptide (Flu-MP), KLH, and peptides derived from the four melanoma antigens: MART-1/Melan A, gp100, tyrosinase, and MAGE-3. A single DC vaccination was sufficient for induction of KLH-specific CD4 T-cell responses in five patients and Flu-MP-specific CD8 T-cell responses in eight patients. A single DC vaccine was sufficient for induction of tumor-specific effectors to at least one melanoma antigen in five patients. Thus, a single injection of CD34 HPC-derived DCs can lead to rapid immune response to CD4 epitopes or to melanoma antigens. |
| Keywords: | adolescent; adult; clinical article; unclassified drug; neoplasm staging; cd8-positive t-lymphocytes; cd34 antigen; dendritic cell vaccine; cancer immunotherapy; melanoma; dendritic cell; tumor antigen; antigen presentation; lymphocyte activation; dendritic cells; cellular immunity; immune response; immunotherapy; antigens, neoplasm; cancer vaccine; cancer vaccines; cd4-positive t-lymphocytes; vaccination; cytotoxicity, immunologic; monophenol monooxygenase; cd4 antigen; antigens, cd34; immunotherapy, adoptive; vaccine; hla-a2 antigen; tumor immunology; cancer; humans; human; priority journal; article |
| Journal Title: | Journal of Immunotherapy |
| Volume: | 26 |
| Issue: | 5 |
| ISSN: | 1524-9557 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2003-09-01 |
| Start Page: | 432 |
| End Page: | 439 |
| Language: | English |
| DOI: | 10.1097/00002371-200309000-00006 |
| PUBMED: | 12973032 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Source: Scopus |
