Chemotherapy and radiation of anal canal cancer: The first approach Journal Article
| Authors: | Eng, C.; Abbruzzese, J.; Minsky, B. D. |
| Article Title: | Chemotherapy and radiation of anal canal cancer: The first approach |
| Abstract: | Since the late 1970's, increasing evidence from single-arm phase II studies has indicated that combined modality therapy yields a complete response rate of approximately 80-90% in most patients with squamous cell cancers of the anal canal. Surgery, most commonly an abdominoperineal resection, is reserved for salvage therapy. Although patients with large primary tumors (≥5 cm) have a lower complete response rate of 50-75%, the majority of patients may be spared a colostomy and have an excellent overall survival. This chapter reviews the recent literature of patients treated for squamous cell, basaloid, and cloacogenic carcinoma (collectively defined as squamous cell cancer) of the anal canal. |
| Keywords: | cancer survival; survival rate; treatment failure; clinical trial; neutropenia; review; salvage therapy; squamous cell carcinoma; carcinoma, squamous cell; cisplatin; fluorouracil; cancer combination chemotherapy; diarrhea; antineoplastic agents; cancer adjuvant therapy; cancer patient; cancer radiotherapy; radiation dose; cancer staging; human immunodeficiency virus infection; cancer incidence; neoplasm staging; cancer grading; bone marrow suppression; basal cell carcinoma; cancer screening; high risk patient; cause of death; skin exfoliation; remission induction; sepsis; mitomycin c; medical literature; antiretrovirus agent; highly active antiretroviral therapy; drug cytotoxicity; immune deficiency; acute toxicity; carcinoma, transitional cell; lymphocyte count; amifostine; colostomy; anus neoplasms; anus carcinoma; interstitial radiation; beam therapy; clinical trials, phase ii; humans; prognosis; human |
| Journal Title: | Surgical Oncology Clinics of North America |
| Volume: | 13 |
| Issue: | 2 |
| ISSN: | 1055-3207 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2004-04-01 |
| Start Page: | 309 |
| End Page: | 320 |
| Language: | English |
| DOI: | 10.1016/j.soc.2003.12.004 |
| PROVIDER: | scopus |
| PUBMED: | 15137959 |
| DOI/URL: | |
| Notes: | Surg. Oncol. Clin. North Am. -- Cited By (since 1996):10 -- Export Date: 16 June 2014 -- CODEN: SOCAF -- Source: Scopus |
