Leptomeningeal metastases Journal Article
| Author: | Demopoulos, A. |
| Article Title: | Leptomeningeal metastases |
| Abstract: | Leptomeningeal metastasis, also known as neoplastic meningitis, carcinomatous meningitis, and meningeal carcinomatosis, occurs when cancer cells gain access to cerebrospinal fluid pathways, travel to multiple sites within the central nervous system, settle, and grow. This disease has become an increasingly important late complication in oncology as patients survive longer, develop more brain metastases, and newer chemotherapies fail to penetrate the blood-brain barrier. The hallmark of clinical presentation is a cancer patient who complains of focal neurologic dysfunction and is found to have multifocal signs on neurologic examination. The clinical course is relentlessly progressive; treatment is limited and cures are the subject of case reports. This article reviews the clinical course of leptomeningeal metastasis and addresses recent developments in its pathophysiology, diagnosis, and treatment. Copyright © 2004 by Current Science Inc. |
| Keywords: | cancer chemotherapy; cancer survival; clinical feature; clinical trial; disease course; review; cancer localization; cancer growth; dose response; drug penetration; side effect; pathophysiology; cancer radiotherapy; cytarabine; methotrexate; neurotoxicity; nuclear magnetic resonance imaging; magnetic resonance imaging; antineoplastic agent; metastasis; bone marrow suppression; dexamethasone; steroid; pathology; thiotepa; monoclonal antibody; cancer invasion; drug fatality; cerebrospinal fluid; meningeal neoplasms; folinic acid; drug response; blood brain barrier; brain metastasis; brain disease; seizure; headache; meningioma; neurological complication; carcinomatous meningitis; leukoencephalopathy; neurologic examination; drug cerebrospinal fluid level; aseptic meningitis; intracranial hypertension; myelitis; cd20 antibody; arachnoiditis; humans; human |
| Journal Title: | Current Neurology and Neuroscience Reports |
| Volume: | 4 |
| Issue: | 3 |
| ISSN: | 1528-4042 |
| Publisher: | Springer |
| Date Published: | 2004-05-01 |
| Start Page: | 196 |
| End Page: | 204 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 15102345 |
| DOI: | 10.1007/s11910-004-0039-z |
| DOI/URL: | |
| Notes: | Curr. Neurol. Neurosci. Rep. -- Cited By (since 1996):35 -- Export Date: 16 June 2014 -- Source: Scopus |
