The evolving landscape of brain metastasis Journal Article
| Authors: | Valiente, M.; Ahluwalia, M. S.; Boire, A.; Brastianos, P. K.; Goldberg, S. B.; Lee, E. Q.; Le Rhun, E.; Preusser, M.; Winkler, F.; Soffietti, R. |
| Article Title: | The evolving landscape of brain metastasis |
| Abstract: | Metastasis, involving the spread of systemic cancer to the brain, results in neurologic disability and death. Current treatments are largely palliative in nature; improved therapeutic approaches represent an unmet clinical need. However, recent experimental and clinical advances challenge the bleak long-term outcome of this disease. Encompassing key recent findings in epidemiology, genetics, microenvironment, leptomeningeal disease, neurocognition, targeted therapy, immunotherapy, and prophylaxis, we review preclinical and clinical studies to provide a comprehensive picture of contemporary research and the management of secondary brain tumors. © 2018 Elsevier Inc. |
| Keywords: | review; nonhuman; cancer immunotherapy; cancer genetics; brain metastasis; cognition; genomics; microenvironment; therapy; meningeal metastasis; prevention; tumor microenvironment; molecularly targeted therapy; human; priority journal; neurocognition |
| Journal Title: | Trends in Cancer |
| Volume: | 4 |
| Issue: | 3 |
| ISSN: | 2405-8025 |
| Publisher: | Cell Press |
| Date Published: | 2018-03-01 |
| Start Page: | 176 |
| End Page: | 196 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 29506669 |
| DOI: | 10.1016/j.trecan.2018.01.003 |
| PMCID: | PMC6602095 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 2 April 2018 -- Source: Scopus |
