Molecular biology of gliomas Journal Article
| Author: | Lassman, A. B. |
| Article Title: | Molecular biology of gliomas |
| Abstract: | Gliomas are the most common primary neoplasm of the brain. Unfortunately, they are often refractory to treatment and portend a poor prognosis. However, recent discoveries have shed light on the molecular events driving glioma growth, including abnormalities of three major molecular pathways: extracellular growth factors and their receptors (eg, EGF/EGFR and PDGF/PDGFR), signal transduction cascades (eg, RAS and AKT), and cell proliferation controls (eg, INK4A-ARF). Each of these abnormalities is described in detail. Efforts to inhibit abnormally activated pathways are underway through multi-institutional clinical trials. Copyright © 2004 by Current Science Inc. |
| Keywords: | signal transduction; epidermal growth factor; platelet derived growth factor; protein kinase b; clinical trial; pathogenesis; review; erlotinib; cancer growth; drug targeting; pathophysiology; brain tumor; glioma; brain neoplasms; cell proliferation; metabolism; imatinib; epidermal growth factor receptor; antineoplastic activity; pathology; platelet derived growth factor receptor; drug design; gefitinib; ras protein; arf protein; molecular biology; cyclin dependent kinase inhibitor; rapamycin; cyclin dependent kinase 4; humans; prognosis; human |
| Journal Title: | Current Neurology and Neuroscience Reports |
| Volume: | 4 |
| Issue: | 3 |
| ISSN: | 1528-4042 |
| Publisher: | Springer |
| Date Published: | 2004-05-01 |
| Start Page: | 228 |
| End Page: | 233 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 15102349 |
| DOI: | 10.1007/s11910-004-0043-3 |
| DOI/URL: | |
| Notes: | Curr. Neurol. Neurosci. Rep. -- Cited By (since 1996):27 -- Export Date: 16 June 2014 -- Source: Scopus |
