Glioma oncogenesis and animal models of glioma formation Journal Article
| Authors: | Lyustikman, Y.; Lassman, A. B. |
| Article Title: | Glioma oncogenesis and animal models of glioma formation |
| Abstract: | Modeled tumors provide an important tool in the development of effective therapies for gliomas. As expected, tumors in mice that are driven by a single pathway abnormality respond dramatically to treatment with an inhibitor of the key pathway. By contrast, human gliomas are far more complex, driven by multiple oncogenic changes. This may explain the disappointing results seen in trials of small-molecule inhibitors as monotherapy for human gliomas. Therefore, the exploration of the specific effects of targeted therapeutics on both the histology and activation status of various pathways in mice is in important tool to understand the molecular underpinnings of treatment success and failure in humans. © 2006 Elsevier Inc. All rights reserved. |
| Keywords: | signal transduction; mitogen activated protein kinase; intercellular signaling peptides and proteins; hydroxyurea; clinical trial; review; erlotinib; cancer growth; nonhuman; temozolomide; glioma; brain neoplasms; animals; mice; cell cycle; gastrointestinal stromal tumor; imatinib; xenograft model antitumor assays; protein tyrosine kinase; chronic myeloid leukemia; carcinogenesis; protein tyrosine kinase inhibitor; temsirolimus; glioblastoma; mammalian target of rapamycin; gefitinib; protein farnesyltransferase inhibitor; tipifarnib; vatalanib; oligodendroglioma; tumor model; receptor protein-tyrosine kinases; molecular biology; cell cycle regulation; growth factor; astrocytoma; everolimus; rapamycin; perifosine |
| Journal Title: | Hematology/Oncology Clinics of North America |
| Volume: | 20 |
| Issue: | 6 |
| ISSN: | 0889-8588 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2006-12-01 |
| Start Page: | 1193 |
| End Page: | 1214 |
| Language: | English |
| DOI: | 10.1016/j.hoc.2006.09.005 |
| PUBMED: | 17113459 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 4 June 2012" - "CODEN: HCNAE" - "Source: Scopus" |
