Stat3 is required for the development of skin cancer Journal Article

   


Authors: Pedranzini, L.; Leitch, A.; Bromberg, J.
Article Title: Stat3 is required for the development of skin cancer
Abstract: Signal transducer and activator of transcription 3 (Stat3) is a transcription factor that is constitutively activated in a variety of human malignancies, including prostate, lung, brain, breast, and squamous cell carcinomas. Inhibition of activated Stat3 leads to decreased proliferation and apoptosis of many cancer-derived cell lines, while the introduction of a constitutively activated form of Stat3 into immortalized human breast epithelial cells and rodent fibroblasts results in cellular transformation. Collectively, these data suggest a role for Stat3 in oncogenesis. A new study from Chan et al. (see related article beginning on page 720) is the first to demonstrate a requirement for Stat3 in de novo epithelial carcinogenesis in vivo. Using the two-step model of chemically induced skin carcinogenesis, the authors demonstrated that mice deficient in Stat3 were completely resistant to skin tumor development.
Keywords: dna binding protein; dna-binding proteins; review; squamous cell carcinoma; note; cell proliferation; mouse; animal; metabolism; animals; mice; stat3 protein; apoptosis; breast cancer; skin neoplasms; skin cancer; lung cancer; cancer cell culture; pathology; keratinocyte; physiology; carcinogenesis; prostate cancer; skin; skin tumor; cell transformation; transactivator protein; fibroblast; breast epithelium; stat3 transcription factor; brain cancer; trans-activators; stat3 protein, human; skin carcinogenesis; cell immortalization; stat3 protein, mouse; humans; human; priority journal
Journal Title: Journal of Clinical Investigation
Volume: 114
Issue: 5
ISSN: 0021-9738
Publisher: American Society for Clinical Investigation  
Date Published: 2004-09-01
Start Page: 619
End Page: 622
Language: English
DOI: 10.1172/jci22800
PROVIDER: scopus
PMCID: PMC514594
PUBMED: 15343379
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85047691138&doi=10.1172%2fJCI22800&partnerID=40&md5=98ede90324799cf0f5158968d261e0bb
Notes: J. Clin. Invest. -- Cited By (since 1996):42 -- Export Date: 16 June 2014 -- CODEN: JCINA -- Source: Scopus
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MSK Authors
  1. Laura Pedranzini
    3 Pedranzini
  2. Jacqueline Bromberg
    141 Bromberg
  3. Andrea Leitch
    2 Leitch
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