Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C Journal Article
| Authors: | Dechow, T. N.; Pedranzini, L.; Leitch, A.; Leslie, K.; Gerald, W. L.; Linkov, I.; Bromberg, J. F. |
| Article Title: | Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C |
| Abstract: | Persistently activated Stat3 is found in many different cancers, including ≈60% of breast tumors. Here, we demonstrate that a constitutively activated Stat3 transforms immortalized human mammary epithelial cells and that this oncogenic event requires the activity of matrix metalloproteinase-9 (MMP-9). By immunohistochemical analysis, we observe a positive correlation between strong MMP-9 expression and tyrosine phosphorylated Stat3 in primary breast cancer specimens. These results demonstrate a relationship between activated Stat3 and MMP-9 in breast oncogenesis. |
| Keywords: | protein expression; protein phosphorylation; dna-binding proteins; nonhuman; animal cell; animals; stat3 protein; reverse transcription polymerase chain reaction; gelatinase b; cell line; enzyme activation; breast neoplasms; animalia; cell transformation, neoplastic; cell transformation; breast tumor; histochemistry; breast epithelium; epithelium cell; epithelial cells; stat3 transcription factor; trans-activators; tumor growth; malignant transformation; breast carcinogenesis; protein isoforms; mammary glands, human; gene expression regulation, enzymologic; cell immortalization; matrix metalloproteinase 9; humans; female; priority journal; article |
| Journal Title: | Proceedings of the National Academy of Sciences of the United States of America |
| Volume: | 101 |
| Issue: | 29 |
| ISSN: | 0027-8424 |
| Publisher: | National Academy of Sciences |
| Date Published: | 2004-07-20 |
| Start Page: | 10602 |
| End Page: | 10607 |
| Language: | English |
| DOI: | 10.1073/pnas.0404100101 |
| PROVIDER: | scopus |
| PMCID: | PMC489981 |
| PUBMED: | 15249664 |
| DOI/URL: | |
| Notes: | Proc. Natl. Acad. Sci. U. S. A. -- Cited By (since 1996):121 -- Export Date: 16 June 2014 -- CODEN: PNASA -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work