Treatment of brain metastases Journal Article
| Authors: | Nguyen, T.; Deangelis, L. M. |
| Article Title: | Treatment of brain metastases |
| Abstract: | Brain metastases are a common complication of cancer, found in approximately 20% of patients at autopsy. The diagnosis is usually established by neuroimaging and carries a poor overall prognosis. Supportive therapies, such as corticosteroids, anticonvulsants, and anticoagulants, are necessary for most patients to address the common medical complications that often accompany brain metastases. These treatments often ameliorate symptoms and signs and improve neurologic function, but they require careful management to minimize their common toxicities. Definitive antitumor treatment may include whole-brain radiotherapy, surgery, stereotactic radiosurgery, and chemotherapy. A multimodal approach can yield prolonged survival of a year or more in some patients, particularly those with limited intracranial disease, high performance status, limited systemic cancer burden, young age, and certain tumor pathologies. However, even patients with poor prognostic factors can have some relief of neurologic symptoms and signs with the institution of therapy. Patients with recurrent brain metastases can also benefit from additional treatment, including all the modalities available at diagnosis. © 2004 Elsevier Inc. All rights reserved. |
| Keywords: | cancer chemotherapy; treatment outcome; fracture; clinical trial; review; cisplatin; fluorouracil; drug penetration; hypertension; multimodality cancer therapy; side effect; methotrexate; topotecan; brain radiation; neuroimaging; neurotoxicity; recurrent cancer; brain neoplasms; antineoplastic agent; cancer diagnosis; diagnostic procedure; carboplatin; unindexed drug; etoposide; palliative therapy; sedation; cyclophosphamide; dexamethasone; steroid; vincristine; pathology; cranial irradiation; age; drug hypersensitivity; hyperglycemia; drug fatality; hypokalemia; insomnia; survival time; disease severity; drug mechanism; etiracetam; oxcarbazepine; phenobarbital; topiramate; hepatomegaly; pancreatitis; diabetes mellitus; radiosurgery; drug response; acne; panniculitis; anticoagulants; warfarin; brain metastasis; cataract; nitrosourea; cognitive defect; seizure; symptomatology; osteoporosis; drug metabolism; intestine perforation; drug blood level; glaucoma; immune deficiency; autopsy; anticonvulsive agent; corticosteroid; psychosis; drug dose regimen; sodium; wound healing impairment; brain function; brain hemorrhage; congestive heart failure; bone necrosis; impotence; phenytoin; performance; brain surgery; teniposide; anticonvulsants; mood disorder; valproic acid; potassium; stevens johnson syndrome; carbamazepine; gabapentin; anticoagulant agent; stereotaxic surgery; myopathy; adrenal insufficiency; lamotrigine; sudden death; exophthalmos; hirsutism; lipomatosis; amenorrhea; peptic ulcer; adrenal cortex hormones; tiagabine; metabolic alkalosis; sodium retention; stomach hemorrhage; humans; prognosis; human; brain pseudotumor; cushingoid syndrome |
| Journal Title: | The Journal of Supportive Oncology |
| Volume: | 2 |
| Issue: | 5 |
| ISSN: | 1544-6794 |
| Publisher: | BioLink Communications |
| Date Published: | 2004-09-01 |
| Start Page: | 405 |
| End Page: | 410 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 15524068 |
| DOI/URL: | |
| Notes: | J. Supportive Oncol. -- Cited By (since 1996):15 -- Export Date: 16 June 2014 -- CODEN: JSOOB C2 - 15524068 -- Source: Scopus |
