Myelopathies in patients with cancer Journal Article
| Authors: | Graber, J. J.; Nolan, C. P. |
| Article Title: | Myelopathies in patients with cancer |
| Abstract: | Myelopathy is a devastating neurologic complication of cancer. The resulting pain, paralysis, and incontinence can turn a patient with cancer from a functioning individual to one who is confined to a chair or bed. Early diagnosis and appropriate therapy can prevent or ameliorate these symptoms and improve both duration of survival and quality of life. Accurate neurologic assessment of patients is crucial for early diagnosis and correct therapy. Myelopathy in patients with cancer is not rare. Epidural spinal cord compression (SCC) affects an estimated 5% of patients with cancer; other disorders such as intramedullary spinal cord metastases, adverse effects of therapy, and paraneoplastic spinal cord syndromes, although less common, are equally devastating. Because of space limitations, this review addresses the pathophysiology, clinical findings, diagnosis, and treatment of only some of the myelopathies that affect patients with cancer (Table 1). Because of new data, epidural SCC and paraneoplastic syndromes are emphasized. ©2010 American Medical Association. All rights reserved. |
| Keywords: | cancer survival; review; cisplatin; clinical trials as topic; pathophysiology; cancer adjuvant therapy; cytarabine; methotrexate; drug megadose; nuclear magnetic resonance imaging; neoplasms; prostate specific antigen; edema; quality of life; infection; pain; carcinoembryonic antigen; dexamethasone; steroid; radiation injury; carmustine; thiotepa; early diagnosis; radiosurgery; spinal cord compression; beta 2 microglobulin; preoperative treatment; epstein barr virus; spinal cord metastasis; spinal cord disease; chorionic gonadotropin beta subunit; alpha fetoprotein; paralysis; serotonin; paraneoplastic neuropathy; incontinence; beta glucuronidase; lactate dehydrogenase isoenzyme; epidural abscess; hyperbaric oxygen; osteomyelitis; spinal cord cancer; spinal cord ischemia; spinal cord surgery; spinal cord diseases |
| Journal Title: | Archives of Neurology |
| Volume: | 67 |
| Issue: | 3 |
| ISSN: | 0003-9942 |
| Publisher: | American Medical Association |
| Date Published: | 2010-03-01 |
| Start Page: | 298 |
| End Page: | 304 |
| Language: | English |
| DOI: | 10.1001/archneurol.2010.20 |
| PUBMED: | 20212227 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: ARNEA" - "Source: Scopus" |
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