Discovery of the kit proto-oncogene Book Section

  


Author: Besmer, P.
Editors: Kitamura, Y.; Miettinen, M.; Hirota, S.; Kanakura, Y.
Article/Chapter Title: Discovery of the kit proto-oncogene
Title Series: Gann Monographs on Cancer Research
Abstract: In a ground breaking series of experiments in 1976, Stehelin, Varmus, Vogt and Bishop provided evidence for the transduction of cellular genes, i.e. proto-oncogenes, by retroviruses and thus proof for the proto-oncogene hypothesis. Subsequently, oncogenes were identified in viruses isolated from several different species and it became clear that oncogenes found in acute transforming retroviruses were not restricted to the species from which the virus was isolated but that homologous oncogenes were identified in viruses isolated from different species. Therefore, oncogene containing acute transforming retroviruses became an invaluable source for the identification of a large number of viral oncogenes and their normal cellular counterparts the proto-oncogenes. As proto-oncogenes promised to have critical roles in controlling cell growth in the normal organisms and in neoplasia, the identification and characterization of new oncogenes in acute transforming retroviruses was highly significant.
Keywords: leukemia; oncoprotein; review; cancer growth; nonhuman; phenotype; stem cell factor; stem cell factor receptor; proto oncogene; interleukin 2; cell growth; granulocyte macrophage colony stimulating factor; interleukin 13; interleukin 4; interleukin 5; interleukin 7; platelet derived growth factor receptor; protein tyrosine kinase; genetic transduction; hybrid protein; fibrosarcoma; messenger rna; virus strain; complementary dna; colony stimulating factor 1; retrovirus; virus protein; oncogene c kit; southern blotting; mast cell; interleukin 3; virus transformation; recombinant dna technology; human; priority journal; interleukin 9; feline leukemia virus
Book Title: Gastrointestinal Stromal Tumor (GIST): From Pathology to Molecular Target Therapy
Volume: 53
ISBN: 978-3-8055-7817-2
Publisher: S. Karger AG  
Publication Place: New York, NY
Date Published: 2004-01-01
Start Page: 81
End Page: 89
Language: English
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-23844447302&partnerID=40&md5=cd652916bac952c1bd231fdb4a4adff7
Notes: Gann Monogr. Cancer Res. -- Export Date: 16 June 2014 -- CODEN: GANMA -- Source: Scopus