A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family Journal Article
| Authors: | Besmer, P.; Murphy, J. E.; George, P. C.; Qiu, F.; Bergold, P. J.; Ledermasn, L.; Snyder, H. W. Jr; Brodeur, D.; Zuckerman, E. E.; Hardy, W. D. |
| Article Title: | A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family |
| Abstract: | A new acute transforming feline retrovirus, the Hardy-Zuckerman 4 feline sarcoma virus (HZ4-FeSV), has been isolated from a feline fibrosarcoma. The viral genome of HZ4-FeSV contains a new oncogene designated v-kit, has the structure 5′ △gag-kit-△pol-△env 3′ and specifies a gag-kit polyprotein of relative molecular mass 80,000. The predicted kit amino-acid sequence displays partial homology with tyrosine-specific protein kinase oncogenes. HZ4-FeSV appears to have been generated by transduction of feline c-kit sequences with feline leukaemia virus. © 1986 Nature Publishing Group. |
| Keywords: | nonhuman; animal cell; heredity; genes; protein kinases; in vitro study; animalia; oncogenes; molecular cloning; oncogene; amino acid sequence; fibrosarcoma; genetic engineering; cell culture; recombination, genetic; cat; base sequence; radioisotope; molecular weight; electrophoresis; retrovirus; retroviridae; cell transformation, viral; gene structure; virus isolation; proto-oncogenes; oncogene proteins, viral; felidae; gene products, gag; unidentified retrovirus; felis catus; priority journal; retroviridae proteins; transforming protein; feline sarcoma virus; sarcoma viruses, feline; leukaemia virus |
| Journal Title: | Nature |
| Volume: | 320 |
| Issue: | 6061 |
| ISSN: | 0028-0836 |
| Publisher: | Nature Publishing Group |
| Date Published: | 1986-04-03 |
| Start Page: | 415 |
| End Page: | 421 |
| Language: | English |
| DOI: | 10.1038/320415a0 |
| PUBMED: | 3007997 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus |
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