Propofol-induced alpha rhythm Journal Article
| Authors: | Feschenko, V. A.; Veselis, R. A.; Reinsel, R. A. |
| Article Title: | Propofol-induced alpha rhythm |
| Abstract: | The electroencephalographic effects of two intravenous sedative/hypnotic drugs, propofol and thiopental, were studied at three stable blood concentrations in 52 normal healthy volunteers. The higher concentration resulted in unresponsiveness (lack of response to auditory/tactile stimuli) in all subjects. This report describes the strong frontal-central rhythms apparent in this state using a quantitative description of oscillatory systems underlying the rhythm. These rhythms occur when sedative drug concentrations are greater than those producing the well-described increase in broadband β-power associated with many sedative drugs. Propofol induces rhythms in the α-range, while thiopental produces rhythms in the β-range. Quasistationary for a period of about 1 h, these rhythms exceed the baseline α-rhythm in power. By their resonant nature, these propofolinduced rhythms are analogous to 'the classic α-rhythm', but quantitative characteristics of the underlying oscillatory systems are different. Baseline properties of the oscillatory system underlying the initial resting α-rhythm recover completely as drug concentration decays to negligible values. Copyright © 2004 S. Karger AG, Basel. |
| Keywords: | adult; controlled study; propofol; dose-response relationship, drug; frontal lobe; infusions, intravenous; normal human; anesthetics, intravenous; thiopental; sedative agent; eeg; oscillation; hypnotic agent; auditory stimulation; humans; human; priority journal; article; drug-induced rhythm; alpha rhythm; beta rhythm; tactile stimulation |
| Journal Title: | Neuropharmacology |
| Volume: | 50 |
| Issue: | 3 |
| ISSN: | 0028-3908 |
| Publisher: | Pergamon-Elsevier Science Ltd |
| Date Published: | 2004-09-01 |
| Start Page: | 257 |
| End Page: | 266 |
| Language: | English |
| DOI: | 10.1159/000079981 |
| PROVIDER: | scopus |
| PUBMED: | 15365226 |
| DOI/URL: | |
| Notes: | Neuropsychobiology -- Cited By (since 1996):28 -- Export Date: 16 June 2014 -- CODEN: NPBYA -- Source: Scopus |
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