Thiopental and propofol affect different regions of the brain at similar pharmacologic effects Journal Article
| Authors: | Veselis, R. A.; Feschenko, V. A.; Reinsel, R. A.; Dnistrian, A. M.; Beattie, B.; Akhurst, T. J. |
| Article Title: | Thiopental and propofol affect different regions of the brain at similar pharmacologic effects |
| Abstract: | Propofol has a greater amnesic effect than thiopental. In this study we tested whether different brain regions were affected by propofol and thiopental at similar drug effects. Changes in regional cerebral blood flow (rCBF) were identified by using SPM99 analysis of images obtained with positron emission tomography with 15O water. Ten right-handed male volunteers (age, 35 ± 10 yr; weight, 74.1 ± 7.5 kg; mean ± SD) were randomized to receive thiopental (n = 4) or propofol (n = 6) to target sedative and hypnotic concentrations with bispectral index (BIS) monitoring. Four positron emission tomography images were obtained during various tasks at baseline and with sedative and hypnotic effects. Two participants receiving propofol were unresponsive at sedative concentrations and were not included in the final analyses. Median serum concentrations were 1.2 and 2.7 μg/mL for sedative and hypnotic propofol effects, respectively. Similarly, thiopental concentrations were 4.8 and 10.6 μg/mL. BIS decreased similarly in both groups. The pattern of rCBF change was markedly different for propofol and thiopental. Propofol decreased rCBF in the anterior (right-sided during sedation) brain regions, whereas thiopental decreased rCBF primarily in the cerebellar and posterior brain regions. At similar levels of drug effect, propofol and thiopental affect different regions of the brain. These differences may help to identify the loci of action for the nonsedative effects of propofol, such as amnesia. |
| Keywords: | adult; middle aged; positron emission tomography; oxygen; propofol; sedation; drug effect; affect; brain; water; functional laterality; hypnosis; amnesia; cerebrovascular circulation; brain region; normal human; anesthetics, intravenous; hypnotics and sedatives; electroencephalography; human experiment; tomography, emission-computed; carbon dioxide; thiopental; reaction time; touch; brain circulation; oxygen 15; bispectral index; humans; human; male; priority journal; article |
| Journal Title: | Anesthesia and Analgesia |
| Volume: | 99 |
| Issue: | 2 |
| ISSN: | 0003-2999 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2004-08-01 |
| Start Page: | 399 |
| End Page: | 408 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 15271714 |
| DOI: | 10.1213/01.ANE.0000131971.92180.DF |
| DOI/URL: | |
| Notes: | Anesth. Analg. -- Cited By (since 1996):40 -- Export Date: 16 June 2014 -- CODEN: AACRA C2 - 15271714 -- Source: Scopus |
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