Methodological standardization for a multi-institutional in vivo trial of localized (31)P MR spectroscopy in human cancer research. In vitro and normal volunteer studies Journal Article
| Authors: | Arias-Mendoza, F.; Zakian, K.; Schwartz, A.; Howe, F. A.; Koutcher, J. A.; Leach, M. O.; Griffiths, J. R.; Heerschap, A.; Glickson, J. D.; Nelson, S. J.; Evelhoch, J. L.; Charles, H. C.; Brown, T. R.; Murphy-Boesch, J.; Stoyanova, R.; Kappler, F.; Negendank, W. G.; Ballon, D.; Payne, G. |
| Article Title: | Methodological standardization for a multi-institutional in vivo trial of localized (31)P MR spectroscopy in human cancer research. In vitro and normal volunteer studies |
| Abstract: | A multi-institutional group has been created to demonstrate the utility of in vivo 31P magnetic resonance spectroscopy (31P-MRS) to study human cancers in vivo. This review is concerned with the novel problems concerning quality control in this large multinational trial of 31P MRS. Our results show that the careful and systematic performance of the quality control tests depicted here (standardized dual 1H/31P tuned radiofrequency probe, quality control procedures, routine use of 1H irradiation while acquiring 31P MR signals) has ensured comparable results between the different institutions. In studies made in vitro, the root-mean-square error was 3.6%, and in muscle of healthy volunteers in vivo the coefficients of variance for the ratios phosphocreatine/nucleotide-triphosphates, phosphocreatine/noise and nucleotide-triphosphate/noise were 12.2, 7.0 and 10.8%, respectively. The standardization of the acquisition protocol for in vivo-localized 31P MR spectroscopy across the different institutions has resulted in comparable in vivo data, decreasing the possible problems related to a research study carried out under a multi-institutional setting. Copyright © 2004 John Wiley & Sons, Ltd. |
| Keywords: | clinical trial; methodology; sensitivity and specificity; neoplasms; quality control; reproducibility of results; variance; tumor markers, biological; signal noise ratio; clinical protocol; in vivo study; in vitro study; oncology; cancer research; health care; standardization; reference standards; tumors; quality assurance, health care; irradiation; research; magnetic resonance spectroscopy; phosphate; phosphorus nuclear magnetic resonance; internationality; volunteer; proton radiation; radiofrequency; human cancer; error; proton; muscle; nucleotide; phosphorus 31; phosphorylcholine; phosphorus isotopes; muscle, skeletal; non-invasive; creatine phosphate; multicenter studies; scintillation probe; multi-institutional trial; humans; human; priority journal; article; human cancer research; localized 31p mr spectroscopy; methodological standardization; radiofrequency probe; variance coefficients; constants and coefficients; ethanolamines |
| Journal Title: | NMR in Biomedicine |
| Volume: | 17 |
| Issue: | 6 |
| ISSN: | 0952-3480 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2004-10-01 |
| Start Page: | 382 |
| End Page: | 391 |
| Language: | English |
| DOI: | 10.1002/nbm.915 |
| PROVIDER: | scopus |
| PUBMED: | 15386624 |
| DOI/URL: | |
| Notes: | NMR Biomed. -- Cited By (since 1996):22 -- Export Date: 16 June 2014 -- CODEN: NMRBE -- Source: Scopus |
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