Imaging therapeutic response in human bone marrow using rapid whole-body MRI Journal Article

   


Authors: Ballon, D.; Watts, R.; Dyke, J. P.; Lis, E.; Morris, M. J.; Scher, H. I.; Uluǧ, A. M.; Jakubowski, A. A.
Article Title: Imaging therapeutic response in human bone marrow using rapid whole-body MRI
Abstract: Whole-body imaging of therapeutic response in human bone marrow was achieved without introduced contrast agents using diffusion-weighted echo-planar magnetic resonance imaging of physiologic water. Bone marrow disease was identified relative to the strong overlying signals from water and lipids in other anatomy through selective excitation of the water resonance and generation of image contrast that was dependent upon differential nuclear relaxation times and self-diffusion coefficients. Three-dimensional displays were generated to aid image interpretation. The geometric distortion inherent in echo-planar imaging techniques was minimized through the acquisition of multiple axial slices at up to 12 anatomic stations over the entire body. Examples presented include the evaluation of therapeutic response in bone marrow during cytotoxic therapy for leukemia and metastatic prostate cancer and during cytokine administration for marrow mobilization prior to stem cell harvest. © 2004 Wiley-Liss, Inc.
Keywords: cancer chemotherapy; leukemia; cytotoxic agent; nonhuman; nuclear magnetic resonance imaging; metastasis; bone marrow; diffusion; lipid; clinical protocol; stem cell transplantation; diagnostic imaging; prostate cancer; prostatic neoplasms; cytokine; three dimensional imaging; leukemia, myeloid; stem cell mobilization; hematopoiesis; water; surgical anatomy; granulocyte colony-stimulating factor; diffusion weighted imaging; signal processing; diffusion coefficient; tumor therapy; body fat; echo-planar imaging; whole body mri; whole body scanner; cancer; humans; male; article; body water
Journal Title: Magnetic Resonance in Medicine
Volume: 52
Issue: 6
ISSN: 0740-3194
Publisher: John Wiley & Sons  
Date Published: 2004-12-01
Start Page: 1234
End Page: 1238
Language: English
DOI: 10.1002/mrm.20291
PROVIDER: scopus
PMCID: PMC2408689
PUBMED: 15562475
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-10044238092&partnerID=40&md5=192f8cbd5465249261dbfc30e98eb7a4
Notes: Magn. Reson. Med. -- Cited By (since 1996):47 -- Export Date: 16 June 2014 -- CODEN: MRMEE -- Source: Scopus
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MSK Authors
  1. Eric Lis
    138 Lis
  2. Michael Morris
    578 Morris
  3. Douglas J Ballon
    49 Ballon
  4. Ann Jakubowski
    457 Jakubowski
  5. Howard Scher
    1130 Scher
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