Spatial mapping of the percentage cellularity in human bone marrow using magnetic resonance imaging Journal Article


Authors: Ballon, D.; Jakubowski, A. A.; Graham, M. C.; Schneider, E.; Koutcher, J. A.
Article Title: Spatial mapping of the percentage cellularity in human bone marrow using magnetic resonance imaging
Abstract: A noninvasive assay for the spatial distribution of the percentage cellularity in human bone marrow is presented. Twelve individuals were studied using two magnetic resonance imaging techniques: (1) fast spin echo imaging with frequency selective presaturation, and (2) three-point chemical shift imaging. The data were compared to results obtained using a previously validated stimulated echo spectroscopic method. The results of this study demonstrate that a measure of the percentage cellularity in bone marrow is possible using magnetic resonance imaging techniques provided that high-quality water or lipid suppression is achieved across the region of interest. Since the method is applicable to bone marrow at any anatomic location, it may prove useful in dosimetric calculations during and after a course of internal or external beam radiotherapy. (C) 1996 American Association of Physicists in Medicine.
Keywords: bone marrow; water; mr; proton spectroscopy; cellularity; chemical shift imaging; inhomogeneity; dixon technique
Journal Title: Medical Physics
Volume: 23
Issue: 2
ISSN: 0094-2405
Publisher: American Association of Physicists in Medicine  
Date Published: 1996-02-01
Start Page: 243
End Page: 250
Language: English
ACCESSION: WOS:A1996TV76800008
DOI: 10.1118/1.597796
PROVIDER: wos
PUBMED: 8668106
Notes: Article -- Source: Wos
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  1. Douglas J Ballon
    49 Ballon
  2. Jason A Koutcher
    278 Koutcher
  3. Martin C Graham
    53 Graham