Diagnosis and management of infectious complications in critically ill patients with cancer Journal Article
| Authors: | Thirumala, R.; Ramaswamy, M.; Chawla, S. |
| Article Title: | Diagnosis and management of infectious complications in critically ill patients with cancer |
| Abstract: | Cancer and its treatments lead to profound suppression of innate and acquired immune function. In this population, bacterial infections are common and may rapidly lead to overwhelming sepsis and death. Furthermore, infections caused by viral and fungal pathogens should be considered in patients who have specific immune defects. As cancer therapies have become more aggressive the risk for infection has increased and many patients require intensive care support. Despite improvements in long-term survival, infections remain a common complication of cancer therapy and accounts for the majority of chemotherapy-associated deaths. By understanding the host defense impairments and likely pathogens clinicians will be better able to guide diagnosis and management of this unique population. © 2010 Elsevier Inc. All rights reserved. |
| Keywords: | cancer chemotherapy; antibiotic agent; busulfan; fludarabine; neutropenia; pathogenesis; review; hepatitis; cisplatin; doxorubicin; nonhuman; solid tumor; paclitaxel; cancer patient; cancer radiotherapy; methotrexate; rituximab; temozolomide; antineoplastic agent; cancer incidence; neoplasms; carboplatin; unindexed drug; infection; neutrophil count; etoposide; incidence; antifungal agent; cyclophosphamide; melphalan; steroid; cancer mortality; risk assessment; febrile neutropenia; lymphocytopenia; drug fatality; survival time; t cell lymphoma; antibiotic resistance; disease severity; hematologic malignancy; cellular immunity; proton pump inhibitor; urinary diversion; ciprofloxacin; graft versus host reaction; sepsis; malignant neoplastic disease; innate immunity; antivirus agent; clostridium difficile infection; virus infection; cancer epidemiology; diagnostic test; bloodstream infection; infection prevention; vancomycin; corticosteroid; adaptive immunity; tacrolimus; chronic lymphatic leukemia; humoral immunity; cotrimoxazole; bacterial infection; catheter infection; candidiasis; mycosis; cyclosporin; infection risk; respiratory tract infection; alemtuzumab; health care access; skin infection; cladribine; moxifloxacin; piperacillin plus tazobactam; critical illness; immunotoxicity; b cell leukemia; critically ill patient; bone marrow depression; central nervous system infection; typhlitis; septic shock; urinary tract obstruction; pyelonephritis; critically ill; immunosuppressed; ceftazidime; fournier gangrene; gastrointestinal infection; infectious diarrhea; parasitosis; soft tissue infection; spleen disease; ureter stent; urogenital tract infection |
| Journal Title: | Critical Care Clinics |
| Volume: | 26 |
| Issue: | 1 |
| ISSN: | 0749-0704 |
| Publisher: | W.B. Saunders Co. |
| Date Published: | 2010-01-01 |
| Start Page: | 59 |
| End Page: | 91 |
| Language: | English |
| DOI: | 10.1016/j.ccc.2009.09.007 |
| PUBMED: | 19944276 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 3" - "Export Date: 20 April 2011" - "CODEN: CCCLE" - "Source: Scopus" |
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