The CBM signalosome: Potential therapeutic target for aggressive lymphoma? Journal Article
| Authors: | Yang, C.; David, L.; Qiao, Q.; Damko, E.; Wu, H. |
| Article Title: | The CBM signalosome: Potential therapeutic target for aggressive lymphoma? |
| Abstract: | The CBM signalosome plays a pivotal role in mediating antigen-receptor induced NF-κB signaling to regulate lymphocyte functions. The CBM complex forms filamentous structure and recruits downstream signaling components to activate NF-κB. MALT1, the protease component in the CBM complex, cleaves key proteins in the feedback loop of the NF-κB signaling pathway and enhances NF-κB activation. The aberrant activity of the CBM complex has been linked to aggressive lymphoma. Recent years have witnessed dramatic progresses in understanding the assembly mechanism of the CBM complex, and advances in the development of targeted therapy for aggressive lymphoma. Here, we will highlight these progresses and give an outlook on the potential translation of this knowledge from bench to bedside for aggressive lymphoma patients. © 2013 Elsevier Ltd. |
| Keywords: | signal transduction; unclassified drug; nonhuman; protein domain; protein function; quality control; protein assembly; protein degradation; immunoglobulin enhancer binding protein; enzyme activation; enzyme activity; enzyme regulation; protein bcl 10; lymphoma; short survey; targeted therapy; protein cleavage; enzyme mechanism; lymphocyte function; protein polymerization; intracellular signaling; molecularly targeted therapy; multiprotein complex; nf-κb; tumor necrosis factor receptor associated factor 6; human; priority journal; cbm complex; card and membrane associated guanylate kinase like domain containing protein 1; mucosa associated lymphoid tissue lymphoma translocation protein 1 |
| Journal Title: | Cytokine & Growth Factor Reviews |
| Volume: | 25 |
| Issue: | 2 |
| ISSN: | 1359-6101 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2014-04-01 |
| Start Page: | 175 |
| End Page: | 183 |
| Language: | English |
| DOI: | 10.1016/j.cytogfr.2013.12.008 |
| PROVIDER: | scopus |
| PUBMED: | 24411492 |
| PMCID: | PMC4080217 |
| DOI/URL: | |
| Notes: | Cytokine Growth Factor Rev. -- Export Date: 2 June 2014 -- CODEN: CGFRF -- Source: Scopus |
