How I treat the peripheral T-cell lymphomas Journal Article
| Authors: | Moskowitz, A. J.; Lunning, M. A.; Horwitz, S. M. |
| Article Title: | How I treat the peripheral T-cell lymphomas |
| Abstract: | The peripheral T-cell lymphomas (PTCLs) encompass a heterogeneous group of diseases that have generally been associated with poor prognosis. The most common PTCLs, peripheral T-cell lymphoma, not otherwise specified, angioimmunoblastic T-cell lymphoma, and anaplastic lymphoma kinase (ALK)-negative anaplastic large cell lymphoma (ALK-negative), despite their unique presentations and histologies, are currently treated similarly. Here we discuss our general approach to the treatment of the most common PTCLs. Based on the best data currently available, which include retrospective analyses and phase 2 prospective studies, ourapproach has involved cyclophosphamide, doxorubicin, vincristine, prednisone-based therapy followed by consolidation in first remission with autologous stemcell transplant. This treatment strategy likely improves the outcomefor patients compared with historical series; however,progressionfree survival rates remain disappointing, ranging from 40%to 50%. This is currently an exciting time in the treatment of PTCL due to the advent of recently approved drugs as well as new targeted agents currently under investigation. In addition, gene expression profiling is allowing for a better understanding of underlying disease biology, improved diagnostic accuracy, and prognostication in PTCL. As a result, over the next few years, we expect a significant shift in our management of these diseases with a move toward more individualized therapy leading to improved outcomes. © 2014 by The American Society of Hematology. |
| Keywords: | adult; human tissue; treatment response; antibiotic agent; antibiotic therapy; prednisone; fatigue; case report; cisplatin; doxorubicin; cancer combination chemotherapy; cancer risk; drug efficacy; drug safety; multimodality cancer therapy; gemcitabine; cancer staging; outcome assessment; positron emission tomography; cancer diagnosis; diagnostic accuracy; cd3 antigen; ki 67 antigen; antigen expression; dacarbazine; protein bcl 2; progression free survival; computer assisted tomography; gene expression profiling; cell infiltration; etoposide; nausea; vomiting; cyclophosphamide; vincristine; autologous stem cell transplantation; ifosfamide; vinblastine; abdominal pain; fever; rash; emergency ward; t lymphocyte receptor beta chain; t lymphocyte receptor gamma chain; peripheral t cell lymphoma; chromatin; fluorodeoxyglucose f 18; bleomycin; colitis; lactate dehydrogenase; cd4 antigen; lymphocyte; romidepsin; pralatrexate; alemtuzumab; night sweat; interferon regulatory factor 4; belinostat; cd30 antigen; human t cell leukemia virus 1; personalized medicine; anaplastic lymphoma kinase; randomized controlled trial (topic); phase 2 clinical trial (topic); phase 3 clinical trial (topic); phase 1 clinical trial (topic); denileukin diftitox; small intestine perforation; intestine infection; intestine anastomosis; small intestine tumor; failure free survival; methylprednisolone sodium succinate; cancer prognosis; brentuximab vedotin; human; male; priority journal; article |
| Journal Title: | Blood |
| Volume: | 123 |
| Issue: | 17 |
| ISSN: | 0006-4971 |
| Publisher: | American Society of Hematology |
| Date Published: | 2014-04-24 |
| Start Page: | 2636 |
| End Page: | 2644 |
| Language: | English |
| DOI: | 10.1182/blood-2013-12-516245 |
| PROVIDER: | scopus |
| PUBMED: | 24615779 |
| PMCID: | PMC4507040 |
| DOI/URL: | |
| Notes: | Blood -- Export Date: 2 June 2014 -- CODEN: BLOOA -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work