Ceramide-rich platforms in transmembrane signaling Journal Article
| Authors: | Stancevic, B.; Kolesnick, R. |
| Article Title: | Ceramide-rich platforms in transmembrane signaling |
| Abstract: | Recent evidence suggests that ceramide regulates stress signaling via reorganization of the plasma membrane. The focus of this review will be to discuss the mechanism by which acid sphingomyelinase (ASMase)-generated ceramide initiates transmembrane signaling in the plasma membrane exoplasmic leaflet. In particular, we review the unique biophysical properties of ceramide that render it proficient in formation of signaling domains termed ceramide-rich platforms (CRPs), and the role of CRPs in the pathophysiology of various diseases. The biomedical significance of CRPs makes these structures an attractive therapeutic target. © 2010. |
| Keywords: | signal transduction; unclassified drug; review; nonhuman; antineoplastic agent; animal; metabolism; animals; protein targeting; diffusion; protein interaction; enzyme activation; infertility; physiology; chemistry; amino terminal sequence; cell membrane; protein transport; tumor; lipid metabolism; membrane transport; bilayer membrane; internalization; vascular disease; membrane lipid; ceramide; ceramides; cell membrane permeability; biophysics; protein lipid interaction; sphingosine 1 phosphate; phase transition; asmase; platforms; cd40 antigen; lysosome enzyme; protein asmase; recombinant asmase; lipid membrane; lipid raft; membrane biology; membrane fusion; membrane stabilization; membrane structure; phospholipid membrane; disorders of lipid and lipoprotein metabolism; membrane fluidity; lipid metabolism disorders; membrane microdomains |
| Journal Title: | FEBS Letters |
| Volume: | 584 |
| Issue: | 9 |
| ISSN: | 0014-5793 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2010-05-01 |
| Start Page: | 1728 |
| End Page: | 1740 |
| Language: | English |
| DOI: | 10.1016/j.febslet.2010.02.026 |
| PUBMED: | 20178791 |
| PROVIDER: | scopus |
| PMCID: | PMC4440589 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 7" - "Export Date: 20 April 2011" - "CODEN: FEBLA" - "Source: Scopus" |
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