A view from Drosophila: Multiple biological functions for individual microRNAs Journal Article
| Authors: | Smibert, P.; Lai, E. C. |
| Article Title: | A view from Drosophila: Multiple biological functions for individual microRNAs |
| Abstract: | microRNAs (miRNAs) comprise an extensive class of post-transcriptional regulatory molecules in higher eukaryotes. Intensive research in Drosophila has revealed that miRNAs control myriad developmental and physiological processes. Interestingly, several of the best-studied miRNAs impact multiple biological processes, often by regulating distinct key target genes in each setting. Here we discuss the roles of some of these pleiotropic miRNAs, and their implications for studying and interpreting the roles of miRNAs in gene regulatory networks. © 2010 Elsevier Ltd. |
| Keywords: | review; nonhuman; protein function; animals; apoptosis; microrna; drosophila; morphogenesis; stem cell; eukaryota; growth regulation; gene control; development; regulation; gene regulatory network; micrornas; wnt1 protein; eukaryote; dendrite; eye development; nerve degeneration; target; gene regulatory networks; circadian rhythm; neuromuscular synapse; genetic pleiotropy |
| Journal Title: | Seminars in Cell and Developmental Biology |
| Volume: | 21 |
| Issue: | 7 |
| ISSN: | 1084-9521 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2010-09-01 |
| Start Page: | 745 |
| End Page: | 753 |
| Language: | English |
| DOI: | 10.1016/j.semcdb.2010.03.001 |
| PUBMED: | 20211749 |
| PROVIDER: | scopus |
| PMCID: | PMC2919623 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 20 April 2011" - "CODEN: SCDBF" - "Source: Scopus" |
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