The evolution and functional diversification of animal microRNA genes Journal Article
| Authors: | Liu, N.; Okamura, K.; Tyler, D. M.; Phillips, M. D.; Chung, W. J.; Lai, E. C. |
| Article Title: | The evolution and functional diversification of animal microRNA genes |
| Abstract: | microRNAs (miRNAs) are an abundant class of 22 nucleotide (nt) regulatory RNAs that are pervasive in higher eukaryotic genomes. In order to fully understand their prominence in genomes, it is necessary to elucidate the molecular mechanisms that can diversify miRNA activities. In this review, we describe some of the many strategies that allow novel miRNA functions to emerge, with particular emphasis on how miRNA genes evolve in animals. These mechanisms include changes in their sequence, processing, or expression pattern; acquisition of miRNA functionality or antisense processing; and de novo gene birth. The facility and versatility of miRNAs to evolve and change likely underlies how they have become dominant constituents of higher genomes. © 2008 IBCB, SIBS, CAS All rights reserved. |
| Keywords: | genetics; review; molecular genetics; animal; metabolism; animals; microrna; rna interference; evolution; animalia; evolution, molecular; gene expression regulation; gene expression regulation, developmental; molecular evolution; molecular sequence data; eukaryota; nucleotide sequence; base sequence; drosophila melanogaster; untranslated rna; micrornas; rna, untranslated; rna processing; rna processing, post-transcriptional; genes, homeobox; homeobox; neofunctionalization; subfunctionalization |
| Journal Title: | Cell Research |
| Volume: | 18 |
| Issue: | 10 |
| ISSN: | 1001-0602 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2008-10-01 |
| Start Page: | 985 |
| End Page: | 996 |
| Language: | English |
| DOI: | 10.1038/cr.2008.278 |
| PUBMED: | 18711447 |
| PROVIDER: | scopus |
| PMCID: | PMC2712117 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 34" - "Export Date: 17 November 2011" - "Source: Scopus" |
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