Alteration of miRNA activity via context-specific modifications of Argonaute proteins Journal Article
| Authors: | Jee, D.; Lai, E. C. |
| Article Title: | Alteration of miRNA activity via context-specific modifications of Argonaute proteins |
| Abstract: | miRNAs are enclosed within Argonaute (Ago) proteins, the downstream effectors of small RNA-mediated gene silencing. Because miRNAs mediate extensive networks of post-transcriptional control, cells have evolved multiple strategies to control their activity with precision. A growing theme of recent years is how post-translational modifications of Ago proteins, such as prolyl hydroxylation, phosphorylation, ubiquitination, and poly-ADP-ribosylation, alter miRNA activity at global or specific levels. In this review, we discuss recent advances in Ago modifications in mammalian cells and emphasize how such alterations modulate small RNA function to coordinate appropriate downstream cellular responses. These findings provide a framework to understand how Ago protein modifications are linked to reorganization of post-transcriptional regulatory networks, enabling dynamic responses to diverse external stimuli and changing environmental conditions. © 2014 Elsevier Ltd. |
| Keywords: | protein phosphorylation; review; nonhuman; mammalia; microrna; protein degradation; epidermal growth factor receptor; phosphorylation; hypoxia; ubiquitination; gene control; virus infection; argonaute protein; t lymphocyte activation; rna induced silencing complex; biogenesis; protein modification; argonaute; adenosine diphosphate ribosylation; hydroxylation; mirna; proline derivative; human; priority journal; parylation |
| Journal Title: | Trends in Cell Biology |
| Volume: | 24 |
| Issue: | 9 |
| ISSN: | 0962-8924 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2014-09-01 |
| Start Page: | 546 |
| End Page: | 553 |
| Language: | English |
| DOI: | 10.1016/j.tcb.2014.04.008 |
| PROVIDER: | scopus |
| PMCID: | PMC4149831 |
| PUBMED: | 24865524 |
| DOI/URL: | |
| Notes: | Export Date: 1 October 2014 -- Source: Scopus |
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