Adult-specific functions of animal microRNAs Journal Article
| Authors: | Sun, K.; Lai, E. C. |
| Article Title: | Adult-specific functions of animal microRNAs |
| Abstract: | MicroRNAs (miRNAs) are ~22 nt RNAs that coordinate vast regulatory networks in animals and thereby influence myriad processes. This Review examines evidence that miRNAs have continuous roles in adults in ways that are separable from developmental control. Adult-specific activities for miRNAs have been described in various stem cell populations, in the context of neural function and cardiovascular biology, in metabolism and ageing, and during cancer. In addition to reviewing recent results, we also discuss methods for studying miRNA activities specifically in adults and evaluate their relative strengths and weaknesses. A fuller understanding of continuous functions of miRNAs in adults has bearing on efforts and opportunities to manipulate miRNAs for therapeutic purposes. © 2013 Macmillan Publishers Limited. All rights reserved. |
| Keywords: | review; nonhuman; phenotype; animals; purkinje cell; apoptosis; microrna; smad protein; transforming growth factor beta; astrocyte; gene function; neural stem cell; age factors; cell differentiation; dna methylation; cell lineage; animalia; skin; b cell lymphoma; lymphocyte differentiation; dna; messenger rna; aging; glucose; lymphoproliferative disease; drosophila melanogaster; transcription factor pax6; hematopoietic stem cell; glucose homeostasis; micrornas; memory; chronic lymphatic leukemia; nervous system development; satellite cell; lipid metabolism; adult stem cell; ataxia; dopaminergic nerve cell; skeletal muscle; learning; circadian rhythm; transcription factor sox9; high density lipoprotein; microrna 223; microrna 124; microrna 132; abc transporter a1; myogenic factor 5; cerebellum degeneration |
| Journal Title: | Nature Reviews Genetics |
| Volume: | 14 |
| Issue: | 8 |
| ISSN: | 1471-0056 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2013-08-01 |
| Start Page: | 535 |
| End Page: | 548 |
| Language: | English |
| DOI: | 10.1038/nrg3471 |
| PROVIDER: | scopus |
| PUBMED: | 23817310 |
| PMCID: | PMC4136762 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 4 September 2013" - "CODEN: NRGAA" - "Source: Scopus" |
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