Chemistry and biochemistry of 13C hyperpolarized magnetic resonance using dynamic nuclear polarization Journal Article


Authors: Keshari, K. R.; Wilson, D. M.
Article Title: Chemistry and biochemistry of 13C hyperpolarized magnetic resonance using dynamic nuclear polarization
Abstract: The study of transient chemical phenomena by conventional NMR has proved elusive, particularly for non-1H nuclei. For 13C, hyperpolarization using the dynamic nuclear polarization (DNP) technique has emerged as a powerful means to improve SNR. The recent development of rapid dissolution DNP methods has facilitated previously impossible in vitro and in vivo study of small molecules. This review presents the basics of the DNP technique, identification of appropriate DNP substrates, and approaches to increase hyperpolarized signal lifetimes. Also addressed are the biochemical events to which DNP-NMR has been applied, with descriptions of several probes that have met with in vivo success. © 2014 The Royal Society of Chemistry.
Journal Title: Chemical Society Reviews
Volume: 43
Issue: 5
ISSN: 0306-0012
Publisher: Royal Society of Chemistry  
Date Published: 2014-03-07
Start Page: 1627
End Page: 1659
Language: English
DOI: 10.1039/c3cs60124b
PROVIDER: scopus
PUBMED: 24363044
PMCID: PMC4086923
DOI/URL:
Notes: Export Date: 3 March 2014 -- CODEN: CSRVB -- Source: Scopus
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