Sampling hyperpolarized molecules utilizing a 1 Tesla permanent magnetic field Journal Article
| Authors: | Tee, S. S.; DiGialleonardo, V.; Eskandari, R.; Jeong, S.; Granlund, K. L.; Miloushev, V.; Poot, A. J.; Truong, S.; Alvarez, J. A.; Aldeborgh, H. N.; Keshari, K. R. |
| Article Title: | Sampling hyperpolarized molecules utilizing a 1 Tesla permanent magnetic field |
| Abstract: | Hyperpolarized magnetic resonance spectroscopy (HP MRS) using dynamic nuclear polarization (DNP) is a technique that has greatly enhanced the sensitivity of detecting 13C nuclei. However, the HP MRS polarization decays in the liquid state according to the spin-lattice relaxation time (T1) of the nucleus. Sampling of the signal also destroys polarization, resulting in a limited temporal ability to observe biologically interesting reactions. In this study, we demonstrate that sampling hyperpolarized signals using a permanent magnet at 1 Tesla (1T) is a simple and cost-effective method to increase T1s without sacrificing signal-to-noise. Biologically-relevant information may be obtained with a permanent magnet using enzyme solutions and in whole cells. Of significance, our findings indicate that changes in pyruvate metabolism can also be quantified in a xenograft model at this field strength. © The Author(s) 2016. |
| Journal Title: | Scientific Reports |
| Volume: | 6 |
| ISSN: | 2045-2322 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2016-09-06 |
| Start Page: | 32846 |
| Language: | English |
| DOI: | 10.1038/srep32846 |
| PROVIDER: | scopus |
| PMCID: | PMC5011774 |
| PUBMED: | 27597137 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 October 2016 -- Source: Scopus |
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